Disease: Optic Atrophy
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962
TGFB1 P01137 transforming growth factor beta 1 Signaling 3.7E-02 0.287 0.962
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
COX2 P00403 cytochrome c oxidase subunit II Enzyme 0.352 0.962
NLRP3 Q96P20 NLR family pyrin domain containing 3 8.1E-04 0.361 0.962
SIRT1 Q96EB6 sirtuin 1 Epigenetic regulator 8.7E-02 0.378 0.885
GJA1 P17302 gap junction protein alpha 1 Cell-cell junction 0.16 0.393 0.885
COMT P21964 catechol-O-methyltransferase Enzyme 1.1E-06 0.400 0.923
DNMT1 P26358 DNA methyltransferase 1 Epigenetic regulator 1.00 0.406 0.885
AHR P35869 aryl hydrocarbon receptor Transcription factor 1.00 0.410 0.923
CASR P41180 calcium sensing receptor G-protein coupled receptor 4.7E-02 0.410 0.846
PROM1 O43490 prominin 1 Transporter 1.9E-22 0.410 0.846
RPE65 Q16518 retinoid isomerohydrolase RPE65 Enzyme 6.5E-14 0.417 0.808
ERCC2 P18074 ERCC excision repair 2, TFIIH core complex helicase subunit Enzyme 7.1E-20 0.420 0.846
GNAS O95467 P63092 P84996 Q5JWF2 GNAS complex locus Enzyme modulator 0.68 0.420 0.885
DECR1 Q16698 2,4-dienoyl-CoA reductase 1 Enzyme 4.5E-14 0.426 0.885
YAP1 P46937 Yes associated protein 1 Enzyme modulator 1.00 0.432 0.808
TBX1 O43435 T-box transcription factor 1 Transcription factor 0.84 0.433 0.808
SPG7 Q9UQ90 SPG7 matrix AAA peptidase subunit, paraplegin Enzyme 2.0E-36 0.436 0.885
PTPN22 Q9Y2R2 protein tyrosine phosphatase non-receptor type 22 3.5E-21 0.438 0.846
COX1 P00395 cytochrome c oxidase subunit I Enzyme 0.441 0.885
ERCC1 P07992 ERCC excision repair 1, endonuclease non-catalytic subunit Enzyme 1.6E-07 0.445 0.846
PLXNA2 O75051 plexin A2 1.1E-06 0.447 0.808
ARSA P15289 arylsulfatase A Enzyme 1.1E-11 0.448 0.923