Disease: Muscle Spasticity
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MS multiple sclerosis 0.599 0.692
ATP6 P00846 ATP synthase F0 subunit 6 Transporter 0.541 0.731
ND3 P03897 NADH dehydrogenase, subunit 3 (complex I) 0.604 0.654
ND5 P03915 NADH dehydrogenase, subunit 5 (complex I) Enzyme 0.531 0.769
NEFL P07196 neurofilament light 0.488 0.769
ATXN8OS P0DMR3 ATXN8 opposite strand lncRNA 0.650 0.423
HSP90B2P Q58FF3 heat shock protein 90 beta family member 2, pseudogene Chaperone 0.558 0.846
SPG16 spastic paraplegia 16 (complicated, X-linked recessive) 0.722 0.423
ATM Q13315 ATM serine/threonine kinase Kinase 5.6E-47 0.374 0.885
SPG11 Q96JI7 SPG11 vesicle trafficking associated, spatacsin 1.6E-39 0.576 0.538
SPG7 Q9UQ90 SPG7 matrix AAA peptidase subunit, paraplegin Enzyme 2.0E-36 0.436 0.885
FIG4 Q92562 FIG4 phosphoinositide 5-phosphatase 2.3E-34 0.551 0.731
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
NEK1 Q96PY6 NIMA related kinase 1 Kinase 1.9E-25 0.575 0.769
IFT122 Q9HBG6 intraflagellar transport 122 2.4E-24 0.560 0.846
SACS Q9NZJ4 sacsin molecular chaperone 1.1E-23 0.606 0.654
POLR3A O14802 RNA polymerase III subunit A Enzyme 1.3E-23 0.538 0.769
SPATA5 Q8NB90 spermatogenesis associated 5 9.1E-20 0.670 0.654
CYP27A1 Q02318 cytochrome P450 family 27 subfamily A member 1 Enzyme 5.3E-19 0.538 0.731
ABCB6 Q9NP58 ATP binding cassette subfamily B member 6 (Langereis blood group) Transporter 8.6E-19 0.431 0.885
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
EXOSC8 Q96B26 exosome component 8 Enzyme 6.9E-15 0.736 0.269
PNKP Q96T60 polynucleotide kinase 3'-phosphatase 3.7E-14 0.553 0.692
SURF1 Q15526 SURF1 cytochrome c oxidase assembly factor Enzyme 1.6E-13 0.578 0.654
DARS2 Q6PI48 aspartyl-tRNA synthetase 2, mitochondrial Enzyme 9.8E-13 0.638 0.577