Disease: Alzheimer disease, familial, type 3
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
AGER Q15109 advanced glycosylation end-product specific receptor Receptor 6.4E-16 0.420 0.885
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
BACE1 P56817 beta-secretase 1 Enzyme 0.88 0.559 0.769
BCHE P06276 butyrylcholinesterase 1.1E-13 0.447 0.923
BCL2 P10415 BCL2 apoptosis regulator Signaling 0.56 0.291 0.885
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
CHI3L1 P36222 chitinase 3 like 1 1.1E-05 0.419 0.885
CLU P10909 clusterin 7.8E-05 0.426 0.885
CSF2 P04141 colony stimulating factor 2 Signaling 0.83 0.330 0.962
CYP2D6 P10635 cytochrome P450 family 2 subfamily D member 6 1.1E-25 0.437 0.885
DRD2 P14416 dopamine receptor D2 G-protein coupled receptor 0.75 0.436 0.846
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
HSPA4 P34932 heat shock protein family A (Hsp70) member 4 1.00 0.394 0.923
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
IL6 P05231 interleukin 6 0.32 0.248 0.962
INS P01308 insulin 0.30 0.445 0.923
KLK6 Q92876 kallikrein related peptidase 6 Enzyme 6.0E-03 0.575 0.654
LAMC2 Q13753 laminin subunit gamma 2 Enzyme modulator 2.9E-12 0.389 0.923
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
MCIDAS D6RGH6 multiciliate differentiation and DNA synthesis associated cell cycle protein 1.3E-02 0.566 0.769
NEFL P07196 neurofilament light 0.488 0.769