Disease: Frontotemporal dementia
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
TNF P01375 tumor necrosis factor Signaling 0.80 0.231 0.962
IGF1 P05019 insulin like growth factor 1 0.27 0.318 0.885
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
LEP P41159 leptin 0.46 0.349 0.846
CASP3 P42574 caspase 3 Enzyme 0.10 0.351 0.923
BRCA1 P38398 BRCA1 DNA repair associated Enzyme 9.2E-29 0.367 0.923
SOD1 P00441 superoxide dismutase 1 Enzyme 0.18 0.379 0.962
LMNA P02545 lamin A/C 1.00 0.384 0.885
HSPA4 P34932 heat shock protein family A (Hsp70) member 4 1.00 0.394 0.923
MAPK8 P45983 mitogen-activated protein kinase 8 Kinase 1.00 0.397 0.885
CHI3L1 P36222 chitinase 3 like 1 1.1E-05 0.419 0.885
GFAP P14136 glial fibrillary acidic protein 1.5E-06 0.421 0.885
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885
SQSTM1 Q13501 sequestosome 1 8.6E-04 0.428 0.885
GSK3B P49841 glycogen synthase kinase 3 beta Kinase 0.96 0.430 0.846
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
ACHE P22303 acetylcholinesterase (Cartwright blood group) Enzyme 1.00 0.445 0.885
PRNP F7VJQ1 P04156 prion protein 6.3E-04 0.445 0.923
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
KHDRBS1 Q07666 KH RNA binding domain containing, signal transduction associated 1 Nucleic acid binding 0.99 0.457 0.846
REG1A P05451 regenerating family member 1 alpha 1.3E-05 0.467 0.846
GTF2H1 P32780 general transcription factor IIH subunit 1 Transcription factor 0.99 0.469 0.846
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
SGSM3 Q96HU1 small G protein signaling modulator 3 Enzyme 3.4E-15 0.469 0.808