Disease: Neoplastic Syndromes, Hereditary
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
MSH2 P43246 mutS homolog 2 Nucleic acid binding 0.90 0.406 0.808
MSH3 P20585 mutS homolog 3 Nucleic acid binding 7.4E-31 0.474 0.769
MSH6 P52701 mutS homolog 6 Nucleic acid binding 3.7E-05 0.462 0.731
MUTYH Q9UIF7 mutY DNA glycosylase Enzyme 1.3E-18 0.521 0.769
NBN O60934 nibrin Nucleic acid binding 2.2E-16 0.467 0.808
NF1 P21359 neurofibromin 1 Enzyme modulator 0.90 0.440 0.885
PALB2 Q86YC2 partner and localizer of BRCA2 3.0E-19 0.485 0.769
PART1 prostate androgen-regulated transcript 1 0.483 0.885
PIK3CA P42336 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Kinase 1.00 0.292 0.923
PIK3CB P42338 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Kinase 1.00 0.322 0.885
PIK3CD O00329 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Kinase 1.00 0.319 0.885
PIK3CG P48736 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Kinase 1.4E-06 0.320 0.885
PKM P14618 pyruvate kinase M1/2 Kinase 0.85 0.482 0.808
PLAU P00749 plasminogen activator, urokinase Enzyme 2.3E-06 0.425 0.923
PMS2 P54278 PMS1 homolog 2, mismatch repair system component Nucleic acid binding 4.5E-27 0.484 0.808
POLD1 P28340 DNA polymerase delta 1, catalytic subunit 2.4E-06 0.507 0.769
POLE Q07864 DNA polymerase epsilon, catalytic subunit 8.0E-27 0.526 0.731
PTCH1 Q13635 patched 1 1.00 0.398 0.885
PTEN P60484 phosphatase and tensin homolog Enzyme 0.26 0.305 0.923
RAD50 Q92878 RAD50 double strand break repair protein 3.4E-27 0.556 0.808
RAD51B O15315 RAD51 paralog B 2.1E-15 0.556 0.769
RAD51C O43502 RAD51 paralog C 6.2E-14 0.533 0.692
RAD51D O75771 RAD51 paralog D 1.1E-09 0.674 0.385
RB1 P06400 RB transcriptional corepressor 1 Nucleic acid binding 1.00 0.444 0.885
RECQL P46063 RecQ like helicase Enzyme 1.5E-20 0.615 0.615