Disease: Hypercholesterolemia, Familial
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ABCA1 O95477 ATP binding cassette subfamily A member 1 Transporter 1.5E-13 0.467 0.846
ABCG5 Q9H222 ATP binding cassette subfamily G member 5 Transporter 3.1E-21 0.592 0.577
ABCG8 Q9H221 ATP binding cassette subfamily G member 8 Transporter 2.4E-20 0.573 0.538
ABO P16442 ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase Enzyme 0.427 0.885
ADRB3 P13945 adrenoceptor beta 3 G-protein coupled receptor 2.5E-07 0.533 0.731
APOA1 P02647 apolipoprotein A1 5.5E-04 0.429 0.885
APOA5 Q6Q788 apolipoprotein A5 5.6E-10 0.587 0.615
APOB P04114 apolipoprotein B 1.9E-16 0.453 0.808
APOC3 P02656 apolipoprotein C3 1.0E-02 0.531 0.731
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APOH P02749 apolipoprotein H 1.6E-15 0.563 0.769
CAD P27708 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase Enzyme 1.00 0.482 0.846
CARM1 Q86X55 coactivator associated arginine methyltransferase 1 Epigenetic regulator 1.00 0.601 0.692
CELSR2 Q9HCU4 cadherin EGF LAG seven-pass G-type receptor 2 G-protein coupled receptor 1.00 0.656 0.577
CETP P11597 cholesteryl ester transfer protein 1.2E-23 0.512 0.731
CXCL8 P10145 C-X-C motif chemokine ligand 8 Signaling 2.7E-04 0.310 0.962
CYP7A1 P22680 cytochrome P450 family 7 subfamily A member 1 Enzyme 2.5E-04 0.576 0.615
ESR1 P03372 estrogen receptor 1 Nuclear receptor 1.00 0.324 0.962
FGB P02675 fibrinogen beta chain Signaling 0.57 0.584 0.692
GLB1 P16278 galactosidase beta 1 Enzyme 7.9E-10 0.448 0.808
HMGCR P04035 3-hydroxy-3-methylglutaryl-CoA reductase 1.00 0.529 0.692
ICAM1 P05362 intercellular adhesion molecule 1 3.5E-02 0.364 0.962
IL6 P05231 interleukin 6 0.32 0.248 0.962
INSIG2 Q9Y5U4 insulin induced gene 2 6.0E-02 0.653 0.500
KANK2 Q63ZY3 KN motif and ankyrin repeat domains 2 4.5E-02 0.638 0.615