Disease: Leigh Disease
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
ATP6 P00846 ATP synthase F0 subunit 6 Transporter 0.541 0.731
BCS1L Q9Y276 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone 4.7E-13 0.534 0.808
C12orf65 Q9H3J6 chromosome 12 open reading frame 65 Nucleic acid binding 0.21 0.678 0.346
COQ4 Q9Y3A0 coenzyme Q4 3.4E-09 0.780 0.269
COQ8A Q8NI60 coenzyme Q8A Kinase 9.3E-11 0.674 0.385
COX1 P00395 cytochrome c oxidase subunit I Enzyme 0.441 0.885
COX10 Q12887 cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10 Enzyme 8.4E-02 0.623 0.654
COX15 Q7KZN9 cytochrome c oxidase assembly homolog COX15 1.1E-13 0.638 0.538
COX3 P00414 cytochrome c oxidase III Enzyme 0.546 0.808
COX8A P10176 cytochrome c oxidase subunit 8A Enzyme 0.12 0.400 0.846
DLD P09622 dihydrolipoamide dehydrogenase Enzyme 9.5E-03 0.517 0.769
ECHS1 P30084 enoyl-CoA hydratase, short chain 1 Enzyme 8.8E-04 0.601 0.654
FARS2 O95363 phenylalanyl-tRNA synthetase 2, mitochondrial Enzyme 9.3E-09 0.615 0.731
FOXRED1 Q96CU9 FAD dependent oxidoreductase domain containing 1 Enzyme 2.0E-16 0.633 0.462
GFM1 Q96RP9 G elongation factor mitochondrial 1 9.3E-13 0.623 0.692
GFM2 Q969S9 G elongation factor mitochondrial 2 Enzyme 1.5E-18 0.736 0.269
GTPBP3 Q969Y2 GTP binding protein 3, mitochondrial 4.2E-09 0.805 0.154
HIBCH Q6NVY1 3-hydroxyisobutyryl-CoA hydrolase Enzyme 2.6E-13 0.700 0.500
LIAS O43766 lipoic acid synthetase 2.3E-05 0.695 0.538
LIPT1 Q9Y234 lipoyltransferase 1 Enzyme 3.8E-08 0.674 0.462
LRPPRC P42704 leucine rich pentatricopeptide repeat containing 2.3E-10 0.493 0.769
MRPS34 P82930 mitochondrial ribosomal protein S34 2.6E-03 0.722 0.346
MTFMT Q96DP5 mitochondrial methionyl-tRNA formyltransferase Enzyme 1.5E-07 0.595 0.808
MTO1 Q9Y2Z2 mitochondrial tRNA translation optimization 1 7.4E-06 0.670 0.462
NARS2 Q96I59 asparaginyl-tRNA synthetase 2, mitochondrial Enzyme 7.1E-08 0.650 0.577