Disease: Motor Neuron Disease
Source: ALL
Gene Uniprot Gene Full Name Protein Class pLI DSI v DPI v
APOE P02649 apolipoprotein E 1.9E-03 0.338 0.962
APP P05067 amyloid beta precursor protein Enzyme modulator 4.7E-02 0.422 0.846
ATXN2 Q99700 ataxin 2 Nucleic acid binding 0.85 0.482 0.808
BDNF P23560 brain derived neurotrophic factor Signaling 0.66 0.345 0.923
C9orf72 Q96LT7 C9orf72-SMCR8 complex subunit 1.1E-06 0.496 0.769
CHMP2B Q9UQN3 charged multivesicular body protein 2B 4.6E-06 0.543 0.731
DCTN4 Q9UJW0 dynactin subunit 4 0.73 0.472 0.846
FUS P35637 FUS RNA binding protein Nucleic acid binding 1.00 0.470 0.846
GRN P28799 granulin precursor 7.0E-02 0.435 0.846
GTF2H1 P32780 general transcription factor IIH subunit 1 Transcription factor 0.99 0.469 0.846
HNRNPA3 P51991 heterogeneous nuclear ribonucleoprotein A3 1.00 0.751 0.308
IGFALS P35858 insulin like growth factor binding protein acid labile subunit Receptor 5.4E-11 0.511 0.846
KHDRBS1 Q07666 KH RNA binding domain containing, signal transduction associated 1 Nucleic acid binding 0.99 0.457 0.846
LRRK2 Q5S007 leucine rich repeat kinase 2 Kinase 2.6E-30 0.510 0.808
LSM2 Q9Y333 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated Nucleic acid binding 2.4E-05 0.650 0.577
MAPT P10636 microtubule associated protein tau 6.0E-03 0.446 0.923
NEFL P07196 neurofilament light 0.488 0.769
NUP62 P37198 nucleoporin 62 Transporter 0.95 0.470 0.885
OPTN Q96CV9 optineurin 5.9E-18 0.548 0.808
PFN1 P07737 profilin 1 0.73 0.565 0.769
PIN1 Q13526 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 0.74 0.488 0.769
PSEN1 P49768 presenilin 1 Enzyme 0.97 0.469 0.846
SIGMAR1 Q99720 sigma non-opioid intracellular receptor 1 0.17 0.544 0.808
SNCA P37840 synuclein alpha Transporter 0.88 0.427 0.885
SNCG O76070 synuclein gamma Transporter 8.5E-04 0.550 0.615