|
rs397517132
|
|
|
0.050 |
GeneticVariation |
BEFREE |
In exon 15, one BRAF mutation (1796 thymine to adenine; V599E) was found in nonsmoking woman with well-differentiated adenocarcinoma.
|
16376942 |
2006 |
|
rs1164376164
|
|
|
0.020 |
GeneticVariation |
BEFREE |
MDR1 T-129C, but not G2677A,T and C3435T, was associated with the lower expression of MDR1 mRNA both in colorectal adenocarcinomas (p=0.040) and adjacent noncancerous colorectal tissues (p=0.023), possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the patients, especially when no extra biopsy samples will be obtained.
|
16819187 |
2006 |
|
rs1045642
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDR1 T-129C, but not G2677A,T and C3435T, was associated with the lower expression of MDR1 mRNA both in colorectal adenocarcinomas (p=0.040) and adjacent noncancerous colorectal tissues (p=0.023), possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the patients, especially when no extra biopsy samples will be obtained.
|
16819187 |
2006 |
|
rs1048943
|
|
|
0.010 |
GeneticVariation |
BEFREE |
CYP1A1 Ile462Val and MPO G-463A interact to increase risk of adenocarcinoma but not squamous cell carcinoma of the lung.
|
16195240 |
2006 |
|
rs1052133
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In the present study, the OGG1-Ser326Cys polymorphism was assessed for association with lung ADC risk using a case-control study of a Japanese population consisting of 1097 cases and 394 controls.
|
16800823 |
2006 |
|
rs1289543302
|
|
|
0.010 |
GeneticVariation |
BEFREE |
MDR1 T-129C, but not G2677A,T and C3435T, was associated with the lower expression of MDR1 mRNA both in colorectal adenocarcinomas (p=0.040) and adjacent noncancerous colorectal tissues (p=0.023), possibly being an useful invasive marker predicting poorly-differentiated colorectal adenocarcinomas and thereby the poor prognosis of the patients, especially when no extra biopsy samples will be obtained.
|
16819187 |
2006 |
|
rs140693
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our findings suggest that the MBD4 Glu346Lys polymorphism could be used as a marker for genetic susceptibility to AC of the lung.
|
16803845 |
2006 |
|
rs16906079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Heterozygous Thr 135 Ala polymorphism at leucine-rich repeat (LRR) in genomic DNA of toll-like receptor 4 in patients with poorly-differentiated gastric adenocarcinomas.
|
16786156 |
2006 |
|
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we report a case of 2 synchronous lung adenocarcinomas composed of 2 distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary subtype of adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma.
|
18186961 |
2007 |
|
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we report a case of 2 synchronous lung adenocarcinomas composed of 2 distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary subtype of adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma.
|
18186961 |
2007 |
|
rs121434568
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Herein, we report a case of 2 synchronous lung adenocarcinomas composed of 2 distinct pathological subtypes with different EGFR mutations: homozygous deletion in exon 19 in the papillary subtype of adenocarcinoma and a point mutation of L858R in exon 21 in the tubular adenocarcinoma.
|
18186961 |
2007 |
|
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A lung biopsy from the left lower lobe disclosed an adenocarcinoma which harbored an in-frame deletion in exon 19 (heterozygous delE746-A750) of EGFR without a second mutation such as T790M in exon 20.
|
17618013 |
2007 |
|
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A gefitinib-resistant point mutation (T790M) in exon 20 without gefitinib treatment was detected in 1 AAH and 1 adenocarcinoma.
|
17561305 |
2007 |
|
rs121434569
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Acquired resistance of pulmonary adenocarcinoma to initially successful targeted therapy due to EGFR mutation T790M.
|
17649787 |
2007 |
|
rs762846821
|
|
|
0.080 |
GeneticVariation |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
|
rs1444669684
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We show here that concomitant expression of Kras(G12D) and haploinsufficiency of the Smad4/Dpc4 tumor suppressor gene engenders a distinct class of pancreatic tumors, mucinous cystic neoplasms (MCNs), which culminate in invasive ductal adenocarcinomas.
|
17349581 |
2007 |
|
rs577715207
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A commercially available monoclonal antibody against S100P</span> stained 78% of 300 urothelial carcinomas while only 2% of 256 prostatic adenocarcinomas</span> and none of 137 renal cell carcinomas stained.
|
17460449 |
2007 |
|
rs373129709
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The aim of the present study was to investigate the relationship between EGF A61G genotype and EGF gene expression levels in colorectal adenocarcinomas and normal colon tissue.
|
17851837 |
2007 |
|
rs751144688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In particular, CEACAM5 , TACSTD1 , S100P , and MSLN have shown to be upregulated in adenocarcinoma, and increased expression levels of CEACAM5 and TACSTD1 were significantly correlated with poorer patient outcomes.
|
18182341 |
2007 |
|
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, 3 of 4 adenocarcinomas with EGFR mutations (all L858R point mutations in women, never or former smokers) had a concomitant and identical mutation in AAH, and 2 of 4 adenocarcinomas with K-ras mutations (both at codon 12 in women, a never and a current smoker) showed the same mutation in concomitant AAH.All cases were wild-type for HER2.
|
18208799 |
2008 |
|
rs1057519847
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this prospective study, EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy.
|
18509184 |
2008 |
|
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this prospective study, EGFR exon 19 deletion or L858R mutations in adenocarcinoma were the best predictors for longer TTF in stage IIIB/IV chemotherapy-naive NSCLC patients receiving first-line gefitinib monotherapy.
|
18509184 |
2008 |
|
rs1057519848
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, 3 of 4 adenocarcinomas with EGFR mutations (all L858R point mutations in women, never or former smokers) had a concomitant and identical mutation in AAH, and 2 of 4 adenocarcinomas with K-ras mutations (both at codon 12 in women, a never and a current smoker) showed the same mutation in concomitant AAH.All cases were wild-type for HER2.
|
18208799 |
2008 |
|
rs113488022
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adenocarcinomas with this clinicopathologic phenotype may be worthwhile investigating for BRAF-V600E mutation as more genetically oriented drug therapies emerge.
|
18636014 |
2008 |
|
rs121434568
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, 3 of 4 adenocarcinomas with EGFR mutations (all L858R point mutations in women, never or former smokers) had a concomitant and identical mutation in AAH, and 2 of 4 adenocarcinomas with K-ras mutations (both at codon 12 in women, a never and a current smoker) showed the same mutation in concomitant AAH.All cases were wild-type for HER2.
|
18208799 |
2008 |