rs429358
|
|
C |
0.890 |
GeneticVariation |
CLINVAR |
|
|
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A total of 23 publications (19 for rs449647, ten for rs769446 and ten for rs405509) were retrieved that included 5,703 patients with AD and 5,692 controls.
|
28900374 |
2017 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among ε4/ε4 individuals, AD risk</span> increased substantially in a dose-dependent manner with the number of <i>APOE</i> promoter SNP rs405509 <i>T</i> alleles in EastAs <i>(TT</i>: OR (odds ratio) = 27.02, <i>p</i> = 8.80 × 10<sup>-94</sup>; <i>GT</i>: OR = 15.87, <i>p</i> = 2.62 × 10<sup>-9</sup>) and EuroAs (<i>TT</i>: OR = 18.13, <i>p</i> = 2.69 × 10<sup>-108</sup>; <i>GT</i>: OR = 12.63, <i>p</i> = 3.44 × 10<sup>-64</sup>), and rs405509-<i>T</i> homozygotes had a younger onset and more severe cortical atrophy than those with <i>G</i>-allele.
|
31426376 |
2019 |
rs429358
|
|
C |
0.890 |
GeneticVariation |
GWASCAT |
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
|
23419831 |
2014 |
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |
rs7412
|
|
|
0.720 |
GeneticVariation |
BEFREE |
APOE gene comprises of three alleles determined by two single nucleotide polymorphisms (rs429358 and rs7412) resulting in the protein isoforms, among which ApoE4 is a confirmed risk factor for Alzheimer's Disease.
|
29776682 |
2018 |
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied.
|
19455140 |
2009 |
rs11542041
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied.
|
19455140 |
2009 |
rs199768005
|
|
|
0.010 |
GeneticVariation |
BEFREE |
ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease.
|
24607147 |
2014 |
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease.
|
21215387 |
2011 |
rs7412
|
|
|
0.720 |
GeneticVariation |
BEFREE |
Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease.
|
21215387 |
2011 |
rs1424027593
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association between the ABCG2 C421A polymorphism and Alzheimer's disease.
|
23827224 |
2013 |
rs761592007
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene.
|
22531416 |
2012 |
rs405509
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
rs405509
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.
|
20885792 |
2010 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Education, sex, and the APOE-rs405509 variant are associated with Alzheimer's disease and cognitive performance.
|
31100889 |
2019 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD).
|
26825091 |
2016 |
rs405509
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease.
|
27259692 |
2016 |
rs1233347077
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Furthermore, there was no evidence of linkage disequilibrium between the VNTR and -174G/C polymorphisms, not supporting a previous reported additive effect of both IL-6 polymorphisms on AD risk.
|
19897004 |
2010 |
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genetic heterogeneity of Alzheimer's disease in subjects with and without hypertension.
|
31055733 |
2019 |
rs405509
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
|
19136949 |
2009 |
rs405509
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
rs7412
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |