|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
We applied our proposed method to explore the relation between the well-known AD risk SNP APOE rs429358 and three baseline brain imaging modalities (i.e., structural magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and F-18 florbetapir PET scans amyloid imaging (AV45)) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database.
|
27277494 |
2016 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Subsequently, to evaluate comprehensively the APOE (apolipoprotein E) haplotype variants (E1/E2/E3/E4), the markers rs7412 and rs429358 were genotyped in 93 AD affected carriers of the E280A mutation.
|
26619808 |
2016 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
The APOE rs429358 variation significantly influenced the brain network characteristics, affecting the activation of nodes as well as the connectivity of edges in aMCI subjects.The cholesterol metabolism pathway gene-based imaging genetics approach may provide new opportunities to understand the mechanisms underlying AD and suggested that APOE rs429358 is a core genetic variation that is associated with disease-related differences in brain function.
|
26985771 |
2016 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing.
|
22975751 |
2014 |
|
rs429358
|
|
C |
0.890 |
GeneticVariation |
GWASCAT |
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.
|
23419831 |
2014 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease.
|
25027320 |
2014 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
GWASCAT |
Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
|
21123754 |
2011 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Apolipoprotein E (APOE) genotype (ε2/ε3/ε4: rs429358 ε4 allele; rs7412 ε2 allele) is strongly associated with both lipid levels and Alzheimer's disease.
|
21215387 |
2011 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
ApoE single nucleotide polymorphisms (SNPs) Cys112Arg (Epsilon-4), and Arg158Cys (Epsilon-2) have been implicated in cardiovascular and Alzheimer's disease, but their role in colorectal cancer (CRC) has not been extensively studied.
|
19455140 |
2009 |
|
rs429358
|
|
|
0.890 |
GeneticVariation |
BEFREE |
Here, we evaluate whether synthetic RNA/DNA oligonucleotides (chimeraplasts) can convert a dysfunctional gene, APOE4 (C, A and E, T, Cys112Arg), a risk factor for Alzheimer's disease and other neurological disorders, into wild-type APOE3.
|
15781970 |
2005 |
|
rs429358
|
|
C |
0.890 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7259620
|
|
G |
0.800 |
GeneticVariation |
GWASDB |
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.
|
23565137 |
2013 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The findings of this literature review and meta-analysis have shown that rs769446 polymorphism in the promoter region of <i>APOE</i> gene could be a risk factor for AD.
|
28900374 |
2017 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
This study aims at examining the APOE promoter polymorphism rs769446 for possible association with AD in a Tunisian population.
|
26563666 |
2016 |
|
rs769446
|
|
|
0.740 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphisms (SNPs) rs449647, rs769446 and rs405509 in the promoter region of the APOE gene have been variously suggested to be epsilon 4-independent risk factors for Alzheimer's disease (AD).
|
19172988 |
2009 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population.
|
29990559 |
2018 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A total of 23 publications (19 for rs449647, ten for rs769446 and ten for rs405509) were retrieved that included 5,703 patients with AD and 5,692 controls.
|
28900374 |
2017 |
|
rs449647
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Therefore this study confirms the role of the rs449647 A/A genotype as risk factor for AD in Italy and suggests that promoter genotypes and APOE haplotypes might have a complex function in AD-associated genetic risk factors.
|
19172988 |
2009 |
|
rs7412
|
|
C |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide analysis of genetic predisposition to Alzheimer's disease and related sex disparities.
|
30636644 |
2019 |
|
rs7412
|
|
T |
0.720 |
GeneticVariation |
GWASCAT |
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
|
30617256 |
2019 |
|
rs7412
|
|
|
0.720 |
GeneticVariation |
GWASCAT |
GWAS on family history of Alzheimer's disease.
|
29777097 |
2018 |