Gene: APOE ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs761592007
rs761592007
APOE
0.020 GeneticVariation BEFREE Autosomal dominant Alzheimer's disease with early frontal lobe involvement associated with the Met239Ile mutation of Presenilin 2 gene. 22531416

2012
dbSNP: rs1167428194
rs1167428194
APOE
0.010 GeneticVariation BEFREE Nonetheless, the AD associated intronic haplotype is linked to the 338A variant of known ECE1b promoter variant, 338C>A (rs213045). 22693153

2012
dbSNP: rs1438607869
rs1438607869
APOE
0.010 GeneticVariation BEFREE These results suggested that PEMT G523A is associated with AD and that the A allele is an APOE ε4-independent risk factor for AD among Han Chinese women. 21881829

2012
dbSNP: rs7259620
rs7259620
APOE
G 0.800 GeneticVariation GWASDB SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. 23565137

2013
dbSNP: rs769449
rs769449
APOE
A 0.700 GeneticVariation GWASCAT GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. 23562540

2013
dbSNP: rs1424027593
rs1424027593
APOE
0.010 GeneticVariation BEFREE Association between the ABCG2 C421A polymorphism and Alzheimer's disease. 23827224

2013
dbSNP: rs405509
rs405509
APOE
T 0.900 GeneticVariation GWASDB Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies. 24755620

2014
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE Three SNPs [rs429358 in APOE: odds ratio (OR)=4.24, 95% confidence interval (CI)=3.01-5.96, P=1.23×10; rs2075650 in APOE: OR=3.57, 95% CI=2.51-5.06, P=1.23×10; and rs677909 in PICALM: OR=0.63, 95% CI=0.49-0.81, P=0.00036, log additive model] were significantly associated with AD susceptibility after correction for multiple testing. 22975751

2014
dbSNP: rs429358
rs429358
APOE
C 0.890 GeneticVariation GWASCAT APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. 23419831

2014
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation GWASCAT SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. 25027320

2014
dbSNP: rs199768005
rs199768005
APOE
0.010 GeneticVariation BEFREE ApoE variant p.V236E is associated with markedly reduced risk of Alzheimer's disease. 24607147

2014
dbSNP: rs981058595
rs981058595
APOE
0.010 GeneticVariation BEFREE There was no difference in the I405V, C629A, and Taq1B polymorphisms between AD and control groups. 24468472

2014
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE The polymorphism of the Apolipoprotein E (APOE) promoter rs405509 can regulate the transcriptional activity of the APOE gene and is related to Alzheimer's disease (AD). 26314833

2015
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 in the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease. 27259692

2016
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Evidence demonstrates that the T allele of the single-nucleotide polymorphism rs405509 as the apolipoprotein E (APOE) promoter is a risk factor for Alzheimer's disease (AD). 26825091

2016
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE We applied our proposed method to explore the relation between the well-known AD risk SNP APOE rs429358 and three baseline brain imaging modalities (i.e., structural magnetic resonance imaging (MRI), fluorodeoxyglucose positron emission tomography (FDG-PET) and F-18 florbetapir PET scans amyloid imaging (AV45)) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. 27277494

2016
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE Subsequently, to evaluate comprehensively the APOE (apolipoprotein E) haplotype variants (E1/E2/E3/E4), the markers rs7412 and rs429358 were genotyped in 93 AD affected carriers of the E280A mutation. 26619808

2016
dbSNP: rs429358
rs429358
APOE
0.890 GeneticVariation BEFREE The APOE rs429358 variation significantly influenced the brain network characteristics, affecting the activation of nodes as well as the connectivity of edges in aMCI subjects.The cholesterol metabolism pathway gene-based imaging genetics approach may provide new opportunities to understand the mechanisms underlying AD and suggested that APOE rs429358 is a core genetic variation that is associated with disease-related differences in brain function. 26985771

2016
dbSNP: rs769446
rs769446
APOE
0.740 GeneticVariation BEFREE This study aims at examining the APOE promoter polymorphism rs769446 for possible association with AD in a Tunisian population. 26563666

2016
dbSNP: rs759721023
rs759721023
APOE
0.010 GeneticVariation BEFREE This locus harbors a low-frequency coding variant (p.G215S, rs72973581, minor allele frequency = 4.3%) conferring a modest but statistically significant protection against AD (p-value = 0.024, odds ratio = 0.57, 95% confidence interval = 0.41-0.80). 27289440

2016
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE Rs449647 and rs405509 polymorphisms of <i>APOE</i> gene were not associated with an increase of risk of AD. 28900374

2017
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE These results demonstrate that the rs405509 T/T allele of APOE causes an age-related cognitive decline in non-demented elderly people, possibly by modulating brain network communication efficiency, which may be beneficial for understanding the neural mechanisms of rs405509-related cognitive aging and AD pathogenesis. 27636845

2017
dbSNP: rs769446
rs769446
APOE
0.740 GeneticVariation BEFREE The findings of this literature review and meta-analysis have shown that rs769446 polymorphism in the promoter region of <i>APOE</i> gene could be a risk factor for AD. 28900374

2017
dbSNP: rs449647
rs449647
APOE
0.730 GeneticVariation BEFREE A total of 23 publications (19 for rs449647, ten for rs769446 and ten for rs405509) were retrieved that included 5,703 patients with AD and 5,692 controls. 28900374

2017
dbSNP: rs405509
rs405509
APOE
0.900 GeneticVariation BEFREE In the presented study, we investigated the association between -491 A/T (rs449647), -427C/T, (rs769446) and -219 T/G (rs405509) single nucleotide polymorphisms (SNPs) of APOE gene and AD risk in the Polish population. 29990559

2018