Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.080 | GeneticVariation | BEFREE | Alzheimer's Disease Neuroimaging Initiative cohort (ADNI; n=237) data, combining both multiplexed proteomics CSF and genotype data, were used to assess the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454). | 28189700 | 2017 |
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0.080 | GeneticVariation | BEFREE | Genetic studies demonstrate an association of the common GRN rs5848 variant that results in reduced PGRN levels with increased risk for AD. | 28070672 | 2017 |
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0.080 | GeneticVariation | BEFREE | The result of the meta-analysis supported T allele of rs5848 within GRN as a risk factor for AD. | 26820675 | 2017 |
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0.080 | GeneticVariation | BEFREE | Stratified analyses showed associations of rs5848 with increased risk of AD and PD in the homozygous and recessive models. | 25578179 | 2015 |
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0.080 | GeneticVariation | BEFREE | Our data indicate that TT allele of rs5848 is associated with increased risk of AD, suggesting that genetic variant of progranulin gene may play an important role in AD development. | 24680777 | 2014 |
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0.080 | GeneticVariation | BEFREE | Similarly, the mRNA levels of granulin were decreased with respect to A allele of rs5848 in the inferior temporal cortex of neuropathologically confirmed AD patients. | 22890097 | 2013 |
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0.080 | GeneticVariation | BEFREE | The homozygous TT genotype of rs5848 may play a role in the genetic risk of AD development, especially in the elderly. | 21212639 | 2011 |
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0.080 | GeneticVariation | BEFREE | However, stratification according to gender revealed a significant male-specific allele, genotype and haplotype association between AD and GRN SNPs rs4792939, rs850713, and rs5848. | 19016491 | 2009 |