| Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
|---|---|---|---|---|---|---|---|---|---|---|
|
0.060 | GeneticVariation | BEFREE | There were no significant group differences in COMT Val158Met alleles and genotype frequencies between patients and controls, for all EDs pooled together [range of odds ratios (ORs): 0.96-1.04, p-values: 0.46-0.97, I<sup>2</sup> = 0%] and when analysing separately patients with AN (ORs: 0.94-1.04, p-values: 0.31-0.61, I<sup>2</sup> = 0%) or BN (ORs: 0.80-1.09, p-values: 0.28-0.64, I<sup>2</sup> = 0-44%). | 29057600 | 2017 |
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|
0.060 | GeneticVariation | BEFREE | The present study explores the effect of a functional polymorphism (Val158Met) in the catechol-O-methyltransferase (COMT) gene on the set-shifting abilities and prefrontal functional connectivity of patients with anorexia nervosa. | 23046831 | 2013 |
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|
0.060 | GeneticVariation | BEFREE | Meta-analytically combined evidence from the present genotypings and the literature search shows that the effect sizes are homogeneous across studies and that rs4680 is not associated with AN. | 22366815 | 2012 |
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|
0.060 | GeneticVariation | BEFREE | Anorexia nervosa and the Val158Met polymorphism of the COMT gene: meta-analysis and new data. | 22366815 | 2012 |
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|
0.060 | GeneticVariation | BEFREE | Association was found between AN-R and several SNPs in the COMT-ARVCF region including the 158Val/Met polymorphism. | 16118784 | 2005 |
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|
0.060 | GeneticVariation | BEFREE | Because we were not able to support the primary hypothesis that Val158Met is a risk factor for AN, we did not perform secondary analysis of minimum body mass index (mBMI), age at onset or illness subtype (restricting or binge purging anorexia). | 14681918 | 2004 |
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0.060 | GeneticVariation | BEFREE | Catechol-O-methyltransferase (COMT) is a candidate gene for mediating susceptibility to AN since it is involved in the dopamine catabolism and because its functional polymorphism (Val/Met 158) determines high (H) and low (L) enzymatic activity alleles. | 11317231 | 2001 |