Evaluating the impact of cytokine SNPs in RA, we identified the G allele of rs1801275 in IL4R<i>α</i> (<i>p</i> = 0.043) and the G allele of rs361525 in TNF<i>α</i> (<i>p</i> = 0.005) as disease-associated risk factors in bivariate analyses.
Previous studies have investigated the association of TNF-α-238G/A (rs361525) and -308G/A (rs1800629) polymorphisms with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE).
The aim of this study was to determine whether the TNF -1031T/C (rs1799964), -376G/A (rs1800750), -308G/A (rs1800629) -238G/A (rs361525), and TNFR1 -609G/T polymorphisms are associated with RA susceptibility in a sample of Mexican patients.