|
rs2194079
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that three single nucleotide polymorphisms (SNPs), rs4836316, rs2194079 and rs4836317 near the TSS are significantly associated with autism following Bonferroni correction (p = 0.0011, p = 0.0088, and p = 0.0023, respectively).
|
28536440 |
2017 |
|
rs2268498
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These findings show for the first time that the rs2268498 SNP localized in the promoter flanking region of the OXTR gene is associated with autistic traits in different ethnic/cultural groups.
|
29027364 |
2017 |
|
rs3746599
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results showed that rs3746599 was significantly associated with autism under allelic, additive and dominant models, respectively (χ<sup>2 </sup>=<sup> </sup>9.699, P = 0.0018; χ<sup>2 </sup>=<sup> </sup>16.224, P = 0.001; χ<sup>2 </sup>=<sup> </sup>7.198, P = 0.007).
|
27223645 |
2017 |
|
rs4836316
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that three single nucleotide polymorphisms (SNPs), rs4836316, rs2194079 and rs4836317 near the TSS are significantly associated with autism following Bonferroni correction (p = 0.0011, p = 0.0088, and p = 0.0023, respectively).
|
28536440 |
2017 |
|
rs4836317
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our results indicate that three single nucleotide polymorphisms (SNPs), rs4836316, rs2194079 and rs4836317 near the TSS are significantly associated with autism following Bonferroni correction (p = 0.0011, p = 0.0088, and p = 0.0023, respectively).
|
28536440 |
2017 |
|
rs587777162
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Children with mutations in this gene have developmental delay, epilepsy, intellectual disability and often autism; the most frequently occurring mutation is G70S.
|
28378778 |
2017 |
|
rs6280
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering the significance of dopaminergic system in psychological and neurological diseases and its association with autism, the hypothesis that genetic variant of dopamine receptor (DRD3), Ser9Gly (rs6280), may influence treatment of autism may be assumed.
|
29249220 |
2017 |
|
rs748128078
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.
|
28283559 |
2017 |
|
rs756790727
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.
|
28283559 |
2017 |
|
rs879254129
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We analyzed several variants located in the GluN2B C terminus and found that three variants in patients with autism (S1415L) or schizophrenia (L1424F and S1452F) (S1413L, L1422F, and S1450F in rodents, respectively) displayed impaired binding to membrane-associated guanylate kinase (MAGUK) proteins.
|
28283559 |
2017 |
|
rs1053972
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We tested the hypothesis that the PCSK6 VNTR polymorphism rs1053972 influences the expression of handedness and aspects of dimensional schizotypy and autism.
|
26921480 |
2016 |
|
rs1169089134
|
|
|
0.010 |
GeneticVariation |
BEFREE |
An artificial neural network (ANN) model was developed from the data of 138 autistic and 138 nonautistic children using GCPII C1561T, SHMT1 C1420T, MTHFR C677T, MTR A2756G, and MTRR A66G as the predictors of autism risk.
|
27755291 |
2016 |
|
rs1882260
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs237889
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition, carriers of the minor risk allele rs237889-A showed significantly increased severity scores, as assessed through the autism diagnostic interview - revised (ADI-R), with highly significant increases in social interaction deficits.
|
26788924 |
2016 |
|
rs3810686
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs3810687
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs3810688
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs4291
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering the relation between the three polymorphisms of ACE (I/D, rs4343 and rs4291) with the level of ACE activity, we have investigated this association with autism, in a case-control study.
|
27082637 |
2016 |
|
rs4343
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Considering the relation between the three polymorphisms of ACE (I/D, rs4343 and rs4291) with the level of ACE activity, we have investigated this association with autism, in a case-control study.
|
27082637 |
2016 |
|
rs5916269
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs6311
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Several studies, yielding so far inconclusive results, have attempted to associate autism with a functional SNP -1438 G/A (rs6311) in the HTR2A promoter region, while possible contribution of epigenetic mechanisms, such as DNA methylation, to HTR2A dysregulation in autism has not yet been investigated.
|
26149086 |
2016 |
|
rs6464926
|
|
|
0.010 |
GeneticVariation |
BEFREE |
A SNP (rs6464926) was significantly associated with autism even after Bonferroni correction (p=0.008).
|
26552012 |
2016 |
|
rs6638575
|
|
|
0.010 |
GeneticVariation |
BEFREE |
According to both the European and the Italian control groups, a 6-marker haplotype on <i>NLGN4X</i> (rs6638575(G), rs3810688(T), rs3810687(G), rs3810686(C), rs5916269(G), rs1882260(T)) was associated with autism (odd ratio = 3.58, <i>p</i>-value = 2.58 × 10<sup>-6</sup> for the European controls; odds ratio = 2.42, <i>p</i>-value = 6.33 × 10<sup>-3</sup> for the Italian controls).
|
27782075 |
2016 |
|
rs740949
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype G-T (rs740949 and rs6464926) was a risk factor for autism (Z=2.655, p=0.008, Global p=0.024).
|
26552012 |
2016 |
|
rs779867
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our study indicated that the rs779867 polymorphism is associated with ASD; thus, results of this study provide supportive evidence of association of the GRM7 gene with ASD.Autism Res 2016, 9: 1161-1168.
|
27312574 |
2016 |