DisGeNET - a database of gene-disease associations

Borderline Personality Disorder, C0006012

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs6265

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.

12524161

2003

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.

12524161

2003

dbSNP:

rs746682028

BDNF ; BDNF-AS

0.020

GeneticVariation

BEFREE

There was no evidence for an allelic or genotypic association of two polymorphisms (-1360C>T and 196G>A) of the BDNF gene with BPD.

12524161

2003

dbSNP:

rs6265

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results.

16152572

2005

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results.

16152572

2005

dbSNP:

rs175174

ZDHHC8

0.010

GeneticVariation

BEFREE

We examined three SNPs of the ZDHHC8 gene, including rs175174, by case-control association in Japanese patients with BPD (N=172) and controls (N=298) or patients with schizophrenia (N=407) and controls (N=497).

16150541

2005

dbSNP:

rs1311223100

SLC18A1

0.010

GeneticVariation

BEFREE

Genotypes of 585 patients with BPD type I and 563 control subjects were obtained for three missense single nucleotide polymorphisms (SNPs) (Thr4Pro, Thr98Ser, Thr136Ile) and four non-coding SNPs (rs988713, rs2279709, rs3735835, rs1497020).

16936705

2006

dbSNP:

rs1390938

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs1497020

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs2270637

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs2270641

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs2279709

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs3735835

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs988713

SLC18A1

0.010

GeneticVariation

BEFREE

16936705

2006

dbSNP:

rs165599

ARVCF ; COMT

0.010

GeneticVariation

BEFREE

These data suggest that COMT genetic variation at SNP rs165599 is associated with BPD I and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.

17547583

2007

dbSNP:

rs6265

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole.

18242852

2008

dbSNP:

rs759834365

BDNF ; BDNF-AS

0.090

GeneticVariation

BEFREE

The study demonstrates that the BDNF C-270T and Val66Met polymorphisms are unlikely to contribute to the genetic predisposition to BPD as a whole.

18242852

2008

dbSNP:

rs1610037

ADCYAP1

0.010

GeneticVariation

BEFREE

Genotyping of seven single nucleotide polymorphisms (rs1893154; rs2846811; rs8192595; rs2856966; rs928978; rs2231187; rs1610037) was performed in BPD patients (n=570) and healthy controls (n=710).

18349695

2008

dbSNP:

rs2284017

CACNG2

0.010

GeneticVariation

BEFREE

None of the 12 genotyped single nucleotide polymorphisms were associated with BPD, but three of them were significantly associated with lithium response: one in both cohorts (rs2284017) and two (rs2284018, rs5750285) each in a different cohort.

18408563

2008

dbSNP:

rs2284018

CACNG2

0.010

GeneticVariation

BEFREE

18408563

2008

dbSNP:

rs29066

VAPA

0.010

GeneticVariation

BEFREE

Single marker analysis revealed an association of rs29067 and rs29066 with BPD; however, after permutation correction, only rs29066 showed a trend towards an allelic association (P = 0.066).

18665321

2008

dbSNP:

rs29067

VAPA

0.010

GeneticVariation

BEFREE

Single marker analysis revealed an association of rs29067 and rs29066 with BPD; however, after permutation correction, only rs29066 showed a trend towards an allelic association (P = 0.066).

18665321

2008

dbSNP:

rs5750285

LOC105373021

0.010

GeneticVariation

BEFREE

18408563

2008

dbSNP:

rs6295

HTR1A

0.010

GeneticVariation

BEFREE

The aim of our study was to determine whether a functional polymorphism of the 5-hydroxytryptamine(1A) receptor (5-HTR(1A)) gene C -1019 G (identity number: rs6295 G/C) is associated with structural changes of the amygdala in patients with BPD.

18387137

2008

dbSNP:

rs2230912

P2RX7 ; LOC105370032

0.020

GeneticVariation

BEFREE

Here we present a case-control analysis of 171 patients diagnosed with MDD or BPD and 178 controls, as well as a dimensional approach using the Hospital Anxiety and Depression Scale (HADS) for studying the Gln460Arg polymorphism of the P2RX7 gene as a genetic risk factor in depression.

18543274

2009