rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Therefore the BRAF V600E mutation is a highly interesting oncological target in brain tumors.
|
27350555 |
2016 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Future clinical trials should address whether BRAF (V600E) mutant brain tumor patients will benefit from BRAF (V600E)-directed targeted therapies.
|
21274720 |
2011 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pleomorphic xanthoastrocytoma is a rare brain tumor with unique high frequency of BRAF V600E mutation which is plausible for targeted therapy.
|
29200156 |
2018 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Emerging evidence support the effectiveness of targeted therapies for brain tumors with BRAF V600E mutation.
|
31345255 |
2019 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Autophagy inhibition improves chemosensitivity in BRAF(V600E) brain tumors.
|
24823863 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Epithelioid glioblastoma is a recognized glioblastoma variant, recently added to the World Health Organization brain tumor classification, with similar prognosis as the classic variant and B-Raf V600E mutations in 50% of the cases.
|
31258848 |
2019 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An activating mutation of BRAF (BRAF-V600E) has been reported in a subset of malignant brain tumors.
|
24721513 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Efficacy of BRAF V600E targeted therapies in brain tumors harboring the mutation has been shown in several case reports and is currently being studied in larger clinical trials.
|
29380516 |
2018 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PKM2-regulated MLC2 phosphorylation, which is greatly enhanced by EGF stimulation or EGFRvIII, K-Ras G12V and B-Raf V600E mutant expression, plays a pivotal role in cytokinesis, cell proliferation and brain tumour development.
|
25412762 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Using BRAF(V600E) as a marker of autophagy dependence in pediatric brain tumors.
|
25484091 |
2014 |
rs121913377
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The BRAF V600E mutation and KIAA1549-BRAF fusion are alterations found in several brain tumors and show a distinct prognostic impact in some entities.
|
31181803 |
2019 |
rs121913338
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs397516896
|
|
G |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs113488022
|
|
T |
0.800 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
rs113488022
|
|
T |
0.800 |
GeneticVariation |
CLINVAR |
Targeted therapy for BRAFV600E malignant astrocytoma.
|
22038996 |
2011 |
rs113488022
|
|
T |
0.800 |
GeneticVariation |
CLINVAR |
Cooperative interactions of BRAFV600E kinase and CDKN2A locus deficiency in pediatric malignant astrocytoma as a basis for rational therapy.
|
22586120 |
2012 |
rs397516896
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |