|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
It is unlikely that HER2 rs1136201 is a risk factor for breast cancer.
|
21474413 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
One single-nucleotide polymorphism at codon 655 indicates a guanine-to-adenine substitution (Ile655Val) in the transmembrane domain-coding region of the HER-2/neu gene reported to be associated with increased risk of breast cancer.
|
21204706 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These study results suggest that Ile655Val polymorphism of the ERBB2 gene do not alter its activity and may not be associated with increased breast cancer risk among Chinese women.
|
17687647 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to clarify the diagnostic and prognostic significance of TNF-alpha and its combination with HER-2 Ile655Val SNP in breast cancer.
|
20872355 |
2011 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Animal studies and protein modeling suggest that the Ile655Val polymorphism located in the transmembrane domain of the HER2 protein might influence breast cancer development by altering the efficiency of homodimerization.
|
15987431 |
2005 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, they provide clinical evidence that HER-2 Ile655Val SNP does affect serum HER-2 levels and it can be regarded as a predictive biomarker for breast cancer patients with poor prognosis.
|
18237248 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Polymorphisms of HER2 Ile655Val and cyclin D1 (CCND1) G870A are not associated with breast cancer risk but polymorphic allele of HER2 is associated with nodal metastases.
|
18237245 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Ile655Val polymorphism of HER-2 gene was associated with a statistically significantly increased risk of breast cancer all above in homozygotes for Val allele.
|
16416013 |
2006 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The present study was conducted to clarify the predictive and prognostic significance of serum TGF-I(2)1 in breast cancer in relation to Ile655Val single nucleotide polymorphism (SNP) of human epidermal growth factor receptor-2 (HER-2).
|
18348656 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genomic DNA from 339 patients with breast cancer and 361 healthy control subjects was examined for the Val(655)Ile polymorphism with a polymerase chain reaction-restriction fragment-length polymorphism-based assay.
|
10699071 |
2000 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the Ile655Val single nucleotide polymorphism (rs1801200) in 1271 incident breast cancer cases, and 1667 controls who were selected from the Nurses' Health Study blood cohort.
|
15970791 |
2005 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The P53 gene codon 72 Arg/Pro and Her2 gene Ile655Val polymorphisms were not associated with the risk of breast cancer in Turkish women.
|
20380571 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A single-nucleotide polymorphism (SNP) at codon 655, resulting in a G-to-A transition (Ile655Val) in the transmembrane domain-coding region of this gene has been associated with an increased risk of breast cancer, particularly among younger women.
|
12166652 |
2002 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The HER2 I655V polymorphism and breast cancer risk in Ashkenazim.
|
14569185 |
2003 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association between the Ile to Val polymorphism at codon 655 of the human epithelial growth factor receptor 2 (HER-2) gene and susceptibility to breast cancer have been reported for almost all ethnic populations, with both positive or negative conclusions.
|
18090908 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Two hundred and four cases and 138 controls were collected to investigate the association of HER-2 Ile655Val polymorphism with the risk of breast cancer development and progression in Iranian population.
|
15374636 |
2004 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In summary, our meta-analysis findings suggest that the HER2 Ile655Val polymorphism is marginally associated with breast cancer susceptibility in worldwide populations with additive and dominant models, but not a recessive model.
|
25520082 |
2014 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our study proposes the allelic imbalance of Ile655Val polymorphism between Greek Christian and Greek Muslim populations of Thrace contributes to the inconsistent association between this SNP and breast cancer risk across these two different ethnic groups.
|
17918664 |
2007 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of HER-2/neu Ile655Val polymorphism and the risk of breast cancer was borderline significant with the heterozygous carrier being at higher risk.
|
18837888 |
2008 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding.
|
14578152 |
2003 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, our meta-analysis suggests that HER2 Ile 655Val polymorphism may contribute to breast cancer risk.
|
20401632 |
2010 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have also evaluated a Val(655)Ile single nucleotide polymorphism, which is associated with an increased risk of breast cancer, in a subset of the colorectal cancer patients and in healthy control subjects.
|
11870539 |
2002 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this analysis, we measured the association between the Ile(655)Val variant and postmenopausal breast cancer among women participating in the Hawaii and Los Angeles Multiethnic Cohort.
|
11731415 |
2001 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We studied the HER2 codon 655 (rs1136201) polymorphism in 80 Austrian patients with BC and 100 healthy volunteers by pyrosequencing and polymerase chain reaction.
|
26637882 |
2015 |
|
rs1136201
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study we aimed to determine whether the risk of breast cancer is associated with the I655V polymorphism of HER2 transmembrane domain-coding region at codon 655.
|
18721072 |
2008 |