Recently, several studies have investigated the association between a newly reported rare functional single nucleotide polymorphism (SNP) in TP53 (rs78378222) and cancer risk, but generated inconsistent findings.
The results indicated that TP53 rs78378222 was significantly associated with an increased risk of overall canc</span>er (AC vs. AA: OR = 1.511, 95% CI = 1.285-1.777).