|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 codon 72 Arg/Pro polymorphism has been suggested to be associated with susceptibility to tobacco-related cancers, but this association remains controversial.
|
12065086 |
2002 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Statistically significant associations were noted between SNPs in beta-catenin and APOE and a positive family history of cancer (beta-catenin: p=0.034, APOE: p=0.033); tumor location and a DCC SNP (p=0.038) and the P53 R72P mutation and survival (p=0.0336).
|
15523694 |
2005 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk.
|
15633234 |
2005 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers.
|
16419081 |
2006 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer.
|
16721787 |
2006 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To explore the impact of the p53 PIN3-Arg72Pro haplotype on colorectal adenoma formation and progression to cancer.
|
17374954 |
2006 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The prognostic significance of the Arg72Pro polymorphism of the p53 tumour suppressor gene in cancer is controversial.
|
17400332 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Arg72Pro substitution did not associate with decreased risk of cancer.
|
17535973 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk.
|
17909070 |
2007 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown that functional polymorphisms at the MDM2 SNP309 T/G and p53 Arg72Pro may be associated with cancer susceptibility.
|
18575717 |
2008 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The germ-line polymorphisms TP53 Arg72Pro and MDM2 SNP309 T>G are risk factors for tumor development and affect response to chemotherapy and survival in several cancers, but their prognostic and predictive value in patients with high-grade osteosarcomas is not yet defined.
|
19451596 |
2009 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the TP53 gene Arg72Pro polymorphism appreciably influence on occurrence of chromosome aberrations in cancer.
|
20512840 |
2010 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility.
|
20886596 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on bladder cancer risk.
|
21156242 |
2010 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TP53 gene polymorphisms, Arg72Pro and PIN3 (+16 bp), can have prognostic and predictive value in different cancers including breast cancer.
|
21365326 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TP53 Arg 72 Pro polymorphism has been reported to be a risk factor for several types of cancer, but its association with pancreatic cancer has not been fully evaluated.
|
21468597 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 Arg72Pro single-nucleotide polymorphism (SNP) was found to be associated with an increased risk of various malignancies.
|
21778786 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism.
|
21976716 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity.
|
22116280 |
2011 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, it is evident from our study that Arg72Pro SNP is implicated in kangri cancer and that the rare, proline-related allele is connected with higher susceptibility to kangri cancer.
|
22249977 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of this report is to determine frequencies and associations of p53 codon 72 arg/pro polymorphism with different types of cancer in Sudan. p53 codon72 arg/pro polymorphism distribution and allele frequencies in 264 samples of different types of cancers were investigated using PCR.
|
23053979 |
2012 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Mouse models for the p53 R72P polymorphism have recently been developed but a role for this SNP in modifying cancer risk in response to viral and chemical carcinogens has yet to be established experimentally.
|
23475592 |
2014 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
p53 gene variants i.e.16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies.
|
23621193 |
2013 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have also found that the ectopic expression of p53-R248W/P72R in MG63 cells promoted cancer stem-like features, as high proliferation rate, sphere formation, clonogenic growth, high migration and invasive ability; furthermore, it strongly increased the levels of stemness proteins.
|
24373920 |
2014 |
|
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 Arg72Pro polymorphism has been proposed to have some effects on host's susceptibility to cancer.
|
24375191 |
2014 |