|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Arg72Pro SNP of p53 has been associated with many types of cancer as well as with survival and longevity.
|
22116280 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting.
|
25768405 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers.
|
16419081 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on bladder cancer risk.
|
21156242 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among various polymorphic variants of TP53 gene, codon 72 polymorphism (Arg72Pro) has been found to be associated with cancer susceptibility, but only few studies have investigated their effect on thyroid cancer risk.
|
25835179 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of TP53 (rs1042522) showed a significantly higher frequency in cancer samples (OR=1.22, 95%CI=1.004-1.481, p-value=0.016) while differences in frequency were not significant within each group (p-value=0.070).
|
23534750 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
As ionizing radiation (IR) treatment is often used in cancer therapy, we sought to test the physiological effects of IR in mouse models of the p53 R72P polymorphism.
|
28594296 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Codon 72 exon 4 polymorphism (Arg72Pro) of the p53 gene has been implicated in cancer risk.
|
15633234 |
2005 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented.
|
30519324 |
2018 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hence, this study explores the single and combined effects of cancer risk, age of onset and cancer type of three single nucleotide polymorphisms (SNPs)-TP53 Pro72Arg, MDM2 SNP285 and SNP309-already described as modifiers on TP53 mutation carriers but not properly investigated in LFS Suggestive patients.
|
26956143 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the p73 G4C14-to-A4T14 homozygous variant genotype might be a risk factor for cancer, especially in combination with the p53 exon 4 Arg72Pro polymorphism.
|
21976716 |
2012 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, the TP53 gene Arg72Pro polymorphism appreciably influence on occurrence of chromosome aberrations in cancer.
|
20512840 |
2010 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Meta-analysis of associations between ATM Asp1853Asn and TP53 Arg72Pro polymorphisms and adverse effects of cancer radiotherapy.
|
25605158 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, increased cancer risks were observed for the TP53 Arg72Pro polymorphism in patients with poorly differential status, clinical stage II, and without lymph node metastasis.
|
26619844 |
2016 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Mouse models for the p53 R72P polymorphism have recently been developed but a role for this SNP in modifying cancer risk in response to viral and chemical carcinogens has yet to be established experimentally.
|
23475592 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No Evidence of Association of the Arg72Pro p53 Gene Polymorphism with Cancer Risk in the Saudi Population: a Meta-Analysis.
|
26320432 |
2015 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Of them, a nonsynonymous polymorphism, Arg72Pro (rs1042522 C>G), has been most extensively studied for the association with cancer risk; however, few studies have investigated its effect on Wilms' tumor.
|
28260929 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our results suggest ethnicity and histological and anatomical sites may modulate the penetrance of Arg72Pro in cancer susceptibility.
|
20886596 |
2011 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
p53 Arg72Pro polymorphism and risk of colorectal adenoma and cancer.
|
16721787 |
2006 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
p53 gene variants i.e.16 bp duplication in intron 3, Arg72Pro in exon 4 and G>A in intron 6 have been reported to modulate susceptibility to various malignancies.
|
23621193 |
2013 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have indicated that the <i>TP53</i> gene Arg72Pro (rs1042522 C>G) polymorphism is associated with susceptibility to various types of cancer.
|
28275206 |
2017 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Previous studies have suggested associations between variants in TP53 (R72P) and MDM2 (SNP309) and cancer risk.
|
17909070 |
2007 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg).
|
24935583 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Prostate adenocarcinoma is one of the leading causes of cancer related mortality in men but still limited knowledge is available about its associated functional SNPs including rs1042522 (Pro72Arg).
|
24935583 |
2014 |
|
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Recent studies have shown that functional polymorphisms at the MDM2 SNP309 T/G and p53 Arg72Pro may be associated with cancer susceptibility.
|
18575717 |
2008 |