Gene: KRAS ×
Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs61761074
rs61761074
KRAS
0.010 GeneticVariation BEFREE Among them, rs61761074 demonstrated a significant correlation with allele frequency in non-small-cell lung cancer (NSCLC). 26648033

2015
dbSNP: rs61764370
rs61764370
KRAS
0.020 GeneticVariation BEFREE We have reported the analysis performed on the role of the polymorphism located in the KRAS-LCS (rs61764370) which is involved in the disruption of the let-7 complementary site in NSCLC patients enrolled within the TAILOR trial, a randomised trial comparing erlotinib versus docetaxel in second line treatment. 26573509

2015
dbSNP: rs61764370
rs61764370
KRAS
0.020 GeneticVariation BEFREE Recently, a variant allele in the 3'UTR of the KRAS gene (rs61764370 T>G) was shown to be associated with an increased risk for developing non-small cell lung cancer, as well as ovarian cancer, and was most enriched in ovarian cancer patients from hereditary breast and ovarian cancer families. 20676756

2011
dbSNP: rs727503108
rs727503108
KRAS
A 0.700 GeneticVariation CLINVAR High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer. 23548132

2013
dbSNP: rs727503108
rs727503108
KRAS
A 0.700 GeneticVariation CLINVAR The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues. 20926413

2011
dbSNP: rs121913238
rs121913238
KRAS
T 0.700 CausalMutation CLINVAR Correlation of clinical features with the mutational status of GM-CSF signaling pathway-related genes in juvenile myelomonocytic leukemia. 19047918

2009
dbSNP: rs727503108
rs727503108
KRAS
A 0.700 GeneticVariation CLINVAR Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. 19396835

2009
dbSNP: rs112445441
rs112445441
KRAS
T 0.700 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081

2008
dbSNP: rs112445441
rs112445441
KRAS
G 0.700 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081

2008
dbSNP: rs121913238
rs121913238
KRAS
T 0.700 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081

2008
dbSNP: rs121913240
rs121913240
KRAS
C 0.700 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081

2008
dbSNP: rs121913240
rs121913240
KRAS
A 0.700 CausalMutation CLINVAR Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma. 18794081

2008
dbSNP: rs121913240
rs121913240
KRAS
A 0.700 CausalMutation CLINVAR Erlotinib for frontline treatment of advanced non-small cell lung cancer: a phase II study. 17062680

2006
dbSNP: rs727503108
rs727503108
KRAS
A 0.700 GeneticVariation CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404

2006
dbSNP: rs112445441
rs112445441
KRAS
T 0.700 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205

2005
dbSNP: rs121913240
rs121913240
KRAS
A 0.700 CausalMutation CLINVAR KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. 15696205

2005
dbSNP: rs112445441
rs112445441
KRAS
G 0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs112445441
rs112445441
KRAS
T 0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs121913238
rs121913238
KRAS
T 0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs121913240
rs121913240
KRAS
C 0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs121913240
rs121913240
KRAS
A 0.700 CausalMutation CLINVAR BRAF and RAS mutations in human lung cancer and melanoma. 12460918

2002
dbSNP: rs397517040
rs397517040
KRAS
A 0.700 GeneticVariation CLINVAR

dbSNP: rs397517040
rs397517040
KRAS
T 0.700 GeneticVariation CLINVAR

dbSNP: rs727503106
rs727503106
KRAS
T 0.700 GeneticVariation CLINVAR

dbSNP: rs121913535
rs121913535
KRAS
0.710 GeneticVariation BEFREE KRAS mutations were found in 18 (7.2%) patients (15 in adenocarcinoma, 2 in squamous cell carcinoma and one in NSCLC-not otherwise specified), including an uncommon substitution G13C. 24040454

2013