Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Clinical activity of afatinib (BIBW 2992) in patients with lung adenocarcinoma with mutations in the kinase domain of HER2/neu. 22325357

2012
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Prevalence, clinicopathologic associations, and molecular spectrum of ERBB2 (HER2) tyrosine kinase mutations in lung adenocarcinomas. 22761469

2012
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR siRNA targeting against EGFR, a promising candidate for a novel therapeutic application to lung adenocarcinoma. 18334834

2008
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Optimization of patient selection for gefitinib in non-small cell lung cancer by combined analysis of epidermal growth factor receptor mutation, K-ras mutation, and Akt phosphorylation. 16638863

2006
dbSNP: rs397516981
rs397516981
ERBB2 ; MIR4728
TGGGCTCCCC 0.700 CausalMutation CLINVAR Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. 15753357

2005