These results suggested that the miR-196a2rs11614913 may contribute to the genetic susceptibility and prognosis for RCC, which may act as a biomarker for RCC occurrence and prognosis.
We found that CT (miR-196a2, C>T rs11614913) was a risk factor for renal cell carcinoma (CT vs. CC: OR = 1.72, 95%CI = 1.05-2.80, <i>P</i> = 0.03, <i>I</i><sup>2</sup> = 66%), especially in Asian population (CT vs. CC: OR = 1.17, 95%CI = 1.04-1.32, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%). miR-146a G>C rs2910164 was a protective factor of urological cancers (C vs. G: OR = 0.87, 95%CI = 0.81-0.93, <i>P</i> < 0.01, <i>I</i><sup>2</sup> = 0%), especially for bladder cancer. miR-499 A>G rs3746444 was correlated with an increased risk of urological cancers, specifically in Asian population.
Although for rs11614913 and rs3746444 polymorphisms, overall analyses suggested negative results, for rs11614913 polymorphism, when subgroup analysis was conducted by cancer type, a significantly decreased risk of renal cell cancer was identified in recessive model.