Source: ALL
Variant Gene Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs6072081
rs6072081
LOC102724968
0.800 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012
dbSNP: rs7017252
rs7017252
CCDC26
0.800 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012
dbSNP: rs7017252
rs7017252
CCDC26
0.800 GeneticVariation GWASDB Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24. 19270707

2009
dbSNP: rs7017252
rs7017252
CCDC26
0.800 GeneticVariation GWASDB A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 20436469

2010
dbSNP: rs7078160
rs7078160
SHTN1
0.800 GeneticVariation GWASCAT Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. 30067744

2018
dbSNP: rs7078160
rs7078160
SHTN1
0.800 GeneticVariation GWASDB A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 20436469

2010
dbSNP: rs742071
rs742071
PAX7
0.800 GeneticVariation GWASDB A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 20436469

2010
dbSNP: rs8001641
rs8001641
LOC105370275
0.800 GeneticVariation GWASDB Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate. 20023658

2010
dbSNP: rs8001641
rs8001641
LOC105370275
0.800 GeneticVariation GWASCAT Investigating the shared genetics of non-syndromic cleft lip/palate and facial morphology. 30067744

2018
dbSNP: rs9439714
rs9439714
PAX7
0.800 GeneticVariation GWASCAT Genome-wide meta-analyses of nonsyndromic orofacial clefts identify novel associations between FOXE1 and all orofacial clefts, and TP63 and cleft lip with or without cleft palate. 28054174

2017
dbSNP: rs9439714
rs9439714
PAX7
0.800 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012
dbSNP: rs987525
rs987525
CCDC26
0.800 GeneticVariation GWASDB A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24. 19656524

2009
dbSNP: rs987525
rs987525
CCDC26
0.800 GeneticVariation GWASCAT A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24. 19656524

2009
dbSNP: rs2235371
rs2235371
IRF6
0.740 GeneticVariation BEFREE Lack of association between IRF6 polymorphisms (rs2235371 and rs642961) and non-syndromic cleft lip and/or palate in a Brazilian population. 19780991

2010
dbSNP: rs2235371
rs2235371
IRF6
0.740 GeneticVariation BEFREE We carried out transmission-disequilibrium testing for V274I in 8003 individual subjects in 1968 families derived from 10 populations with ancestry in Asia, Europe, and South America, haplotype and linkage analyses, and case-control analyses, and determined the risk of cleft lip or palate that is associated with genetic variation in IRF6. 15317890

2004
dbSNP: rs2235371
rs2235371
IRF6
0.740 GeneticVariation BEFREE Association analysis between the IRF6 G820A polymorphism and nonsyndromic cleft lip and/or cleft palate in a Chinese population. 19115793

2009
dbSNP: rs2235371
rs2235371
IRF6
0.740 GeneticVariation BEFREE In the single locus analyses, we found rs642961 AG and AG/AA genotypes were associated with increased risk of NSOC, especially cleft lip with or without cleft palate (CL/P) and cleft lip with cleft palate (CLP), while significantly decreased risks were associated with rs2235371 CT and CT/TT genotypes. 20799332

2010
dbSNP: rs4791774
rs4791774
NTN1
0.710 GeneticVariation BEFREE Non-syndromic cleft lip with or without palate-susceptible loci rs4791774 (A > G) and rs13041247 (T > C) were associated with the risk of supernumerary teeth. 31233659

2019
dbSNP: rs560426
rs560426
ABCA4
0.710 GeneticVariation GWASDB SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. 20436469

2010
dbSNP: rs560426
rs560426
ABCA4
0.710 GeneticVariation BEFREE SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. 20436469

2010
dbSNP: rs10174126
rs10174126
SH3BP4
0.700 GeneticVariation GWASDB Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts. 22419666

2012
dbSNP: rs1030608
rs1030608
CCDC26
0.700 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012
dbSNP: rs1030609
rs1030609
CCDC26
0.700 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012
dbSNP: rs1044516
rs1044516
IRF6 ; C1orf74
0.700 GeneticVariation GWASDB A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4. 20436469

2010
dbSNP: rs10511145
rs10511145 		0.700 GeneticVariation GWASDB Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. 22863734

2012