rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
Polymorphisms of NOD2 (R702W, G908R and L1007fs) and TLR4 (Asp299Gly and Thr399Ile) genes were analyzed in 106 patients with IBD (68 with ulcerative colitis [UC], 38 with Crohn's disease [CD]) and 160 healthy controls using polymerase chain reaction-restriction fragment length polymorphism.
|
29055077 |
2017 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The TLR4 Thr399Ile polymorphism was associated with UC risk in pooled results as well as subgroup analysis of high quality publications assessing Caucasians, in allele and dominant models.
|
26023918 |
2015 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
T399I showed significant association with UC (P=0.006) but not with CD patients.
|
23470644 |
2013 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The presence of TLR-4 Asp299Gly and TLR-4 Thr399Ile polymorphisms is related to UC pancolitis, involvement of the colon in CD, and lower ACCA IgA levels.
|
22918682 |
2013 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The meta-analysis showed that TLR4 D299G and T399I confer a significant risk for developing CD and UC in Caucasians.
|
20093834 |
2010 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide polymorphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007finsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy.
|
18680223 |
2008 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
The TLR4 Asp299Gly and Thr399Ile polymorphisms were genotyped and tested for case-control frequency differences in a New Zealand white cohort of 389 Crohn's disease (CD) patients, 405 ulcerative colitis (UC) patients, and 416 population controls.
|
17850411 |
2007 |
rs4986791
|
|
|
0.080 |
GeneticVariation |
BEFREE |
In further exploring the genetic background of these diseases, we investigated the variations in the CARD15/NOD2 gene (Arg702Trp, Gly908Arg and Leu1007fsinsC), and polymorphisms in the TLR4 gene (Asp299Gly and Thr399Ile) as well as in the promoter of the CD14 gene (T/C at position -159) in Greek patients with CD and UC.
|
15655821 |
2005 |