The results also showed a significant association between rs1800629 and an IBD-associated CRC population (heterozygous model: OR 4.335, 95% CI 2.329-8.069, P < 0.001; homozygous model: OR 11.5, 95% CI 2.498-52.592, P = 0.002; dominant model: OR 4.986, 95% CI 2.754-9.026, P < 0.001; recessive model: OR 7.208, 95% CI 1.588-32.72, P = 0.01).
The association of <i>TNF</i>-α <b>-</b>308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive.
Polymorphisms of LBP (rs1739654, rs2232596, rs2232618), CD14 (rs77083413, rs4914), TLR-4 (rs5030719), IL-6 (rs13306435) and TNF-α (rs35131721) were genotyped in 479 cases of sporadic colorectal carcinoma and 486 healthy controls of Han Chinese in a case-control study.