rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Identification of Susceptibility Loci and Genes for Colorectal Cancer Risk.
|
26965516 |
2016 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
|
28467803 |
2017 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Large-Scale Genome-Wide Association Study of East Asians Identifies Loci Associated With Risk for Colorectal Cancer.
|
30529582 |
2019 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our data suggest that SMAD7 rs4939827 and CHI3L1 rs4950928 SNPs have no significant association with CRC.
|
26779637 |
2016 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Genome-wide association study of colorectal cancer identifies six new susceptibility loci.
|
26151821 |
2015 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk.
|
24836286 |
2014 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Results from our case-control study and the meta-analysis collectively confirmed the significant association of the variant rs4939827 with increased risk of colorectal cancer.
|
22457752 |
2012 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
A decreased risk for CRC cancer was observed for the CC compared to the TT genotype (OR = 0.65 and 95% CI = 0.51-0.81) of the rs4939827 SNP Also, we could show an association between the Mediterranean diet pattern (protective factor) and rs4939827.
|
29084532 |
2017 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our results show association of rs4939827 with colorectal cancer</span> risk in Croatian population.
|
24066093 |
2013 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
|
23266556 |
2013 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two recent genome-wide association studies (GWAS) identified three common variants in SMAD7 (rs4464148, rs4939827 and rs12953717) that confer modest susceptibility to colorectal cancer.
|
19357349 |
2009 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Genome-wide association scan identifies a colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21.
|
18372901 |
2008 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
We confirmed the association of CRC risk with four SNPs, with odds ratio (OR) higher than previously reported: rs16892766 on 8q23.3 (OR: 1.88, 95% confidence interval (CI): 1.30-2.72; P=0.0007); rs4779584 on 15q13.3 (OR: 1.42, CI: 1.11-1.83; P=0.0061) and rs4939827 and rs58920878/Novel 1 on 18q21.1 (OR: 1.49, CI: 1.13-1.98; P=0.007 and OR: 1.49, CI: 1.14-1.95; P=0.0035).
|
25873010 |
2016 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASDB |
Across the four sample sets, the association between rs4939827 and CRC was highly statistically significant (P(trend) = 1.0 x 10(-12)).
|
17934461 |
2007 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Subgroup analysis according to ethnicity showed rs4464148 and rs12953717 were associated with the risk of CRC in both Caucasians and Asians, whereas rs4939827 was a risk polymorphism for CRC specifically in Caucasians.
|
28070019 |
2016 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those with CRC, the minor allele (G) in rs4939827 was significantly associated with poorer overall survival (hazards ratio, 1.20; 95% CI, 1.02-1.42).
|
23104301 |
2013 |
rs4939827
|
|
T |
0.900 |
GeneticVariation |
GWASCAT |
Novel Common Genetic Susceptibility Loci for Colorectal Cancer.
|
29917119 |
2019 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Two previous genome-wide association studies identified three single nucleotide polymorphisms (SNPs) (rs4939827, rs12953717 and rs4464148) in SMAD7 to be associated with colorectal cancer in a Western population.
|
21221812 |
2011 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.
|
19011631 |
2008 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Moreover, we found cumulative effects of three genetic factors (rs7758229, rs6983267, and rs4939827 in SMAD7) and one environmental factor (alcohol drinking) which appear to increase CRC risk approximately twofold.
|
21242260 |
2011 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
SNPs rs7229639 and rs4939827 explained approximately 1% of the familial relative risk of CRC</span> in East Asians.
|
24448986 |
2014 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Meta-analysis of new genome-wide association studies of colorectal cancer risk.
|
21761138 |
2012 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Furthermore, the A allele of rs7014346, the A allele of rs10505477, and the T allele of rs4939827 were significantly related with an elevated risk of CRC only among Caucasian.Our study suggested that for CASC8 gene, SNP of rs7837328 and rs6983267 are risk factors for CRC among both Caucasian and Asian whereas rs7014346 and rs10505477 are risky gene polymorphisms only among Caucasian.
|
26579801 |
2015 |
rs4939827
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Among those without distant disease at diagnosis, CRC-specific survival differed by genotype only for NSAID users: each minor allele of rs4939827 was associated with worse survival [hazard ratio (HR) = 2.67, 95% confidence interval (CI): 1.33-5.37] and each minor allele of rs4464148 was associated with better survival (HR = 0.41, CI 0.18-0.94).
|
21910156 |
2011 |