rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study replicated an association of <i>CCAT2</i> rs6983267 with CRC and an interaction between <i>TP53</i> rs1042522 and NSAID in relation to CRC.
|
30841568 |
2019 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45).
|
16721787 |
2006 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
|
21051533 |
2011 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The study results revealed that the rs1042522 genotype with the C allele and the rs12947788 genotype with the T allele in TP53 were associated with a decreased CRC risk in patients with Lynch syndrome in Taiwan.
|
27907203 |
2016 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We have previously reported that the common, functionally different variants Arg72Pro in p53 and Arg462Gln in RNASEL are associated with the age of disease onset of colorectal cancer in Lynch syndrome patients.
|
17224235 |
2007 |
rs1042522
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Thus, our current meta-analysis indicates no evidence for the association between the p53 Arg72Pro polymorphism and CRC risk in the Asian population, but significant association in Chinese population, especially for rectal cancer and in men.
|
30316510 |
2018 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, heterozygosity and mutant homozygosity as well as the combination of both TP53 Arg72Pro and CDH1 rs16260 polymorphisms are responsible to increase the risk of colorectal cancer development in Bangladeshi population.
|
28554075 |
2017 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
TP53 R72P and MDM2 SNP309 polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study.
|
21051533 |
2011 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Unexpectedly no significant association was found between this potential marker TP53 Arg72Pro and CRC (p > 0.05).
|
25537146 |
2015 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Among 442 colorectal cancer cases and 904 controls, we observed no significant overall association between p53 Arg72Pro genotype and colorectal cancer (multivariate OR = 1.14, 95% CI = 0.90-1.45).
|
16721787 |
2006 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Few reports have investigated the association of two p53 polymorphisms (Arg72Pro and PIN3-A2) with colorectal cancer (CRC) risk, and no previous study has analyzed their role as susceptibility alleles for colorectal adenoma.
|
17374954 |
2006 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of Arg72Pro of P53 polymorphism with colorectal cancer susceptibility risk in Malaysian population.
|
22393962 |
2011 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We assessed the association of TP53 Arg72Pro and p53PIN3 polymorphisms with colorectal cancer risk and their possible interaction with nonsteroidal anti-inflammatory drug use.
|
17622940 |
2007 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The SNP rs4938723 and diabetes mellitus (DM) together were associated with an increased CRC risk, but the SNP TP53 Arg72Pro CC with DM showed a protective effect against CRC.
|
24337371 |
2014 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We searched multiple electronic databases to identify studies investigating the association between the Arg72Pro polymorphism and colorectal cancer.
|
20615891 |
2010 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We found that the TP53 Arg72Pro polymorphism was not significantly associated with CRC risk in the overall population.
|
27901479 |
2017 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our data suggest that R72P variant seems to be associated with high risk for development of CRC but carries low risk for development of UC.
|
20309662 |
2010 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The p53 R72P genotype was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method in 78 consecutive colorectal cancer patients with liver metastases and 214 age- and sex-matched cases with nonmetastatic colorectal cancer.
|
18988302 |
2008 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that the TP53 R72P polymorphism may contribute to the etiology of colorectal cancer in the Chinese population, particularly among alcohol consumers.
|
17599946 |
2007 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Association of mRNA expression of TP53 and the TP53 codon 72 Arg/Pro gene polymorphism with colorectal cancer risk in Asian population: a bioinformatics analysis and meta-analysis.
|
29872345 |
2018 |
rs1131691014
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that Arg72Pro SNP is associated with susceptibility to developing CRC in this ethnic Kashmiri population.
|
20449797 |
2010 |