|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
To verify the technical characteristics of the microarray system for the correct identification of the KRAS mutational status at the two hotspot codons 12 and 13 and of the BRAF(V600E) mutation in colorectal tumor, we selected 75 samples previously characterized by conventional and CO-amplification at Lower Denaturation temperature-PCR (COLD-PCR) followed by High Resolution Melting analysis and direct sequencing.
|
23536897 |
2013 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
BRAF V600E mutation testing of colorectal tumors demonstrating aberrant MLH1 protein expression by IHC was the most common secondary tumor test, with 53% of laboratories performing the test; 15% of laboratories also applied the BRAF V600E test to endometrial tumors with aberrant MLH1 expression despite no evidence for its utility.
|
30294856 |
2018 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Recently, a V599E hotspot mutation within the BRAF gene was reported in a high percentage of colorectal tumors and significantly associated to defective mismatch repair (MMR).
|
14668801 |
2003 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Rac1b overexpression and B-Raf(V600E) are significantly associated in primary colorectal tumors (P = .008) and colorectal cell lines.
|
18602919 |
2008 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors.
|
19213871 |
2009 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Secondly, considering the alternative possibility, we identified genes whose DNA hypermethylation was closely linked to BRAF(V600E) and CIMP in 235 primary colorectal tumors.
|
20027224 |
2009 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
In addition, a significant association between mismatch-repair (MMR) deficiency and the V599E mutation in colorectal tumors has been found.
|
14654916 |
2004 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
The major aim of this study was to evaluate the performance of anti-BRAF V600E (VE1) antibody in colorectal tumors with and without KRAS mutation.
|
29127628 |
2019 |
|
rs113488022
|
|
|
0.790 |
GeneticVariation |
BEFREE |
Our results support the use of VE1 IHC for identification of colorectal neoplasms harboring the BRAF V600E mutation.
|
25517872 |
2015 |
|
rs6983267
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Allelic imbalance at rs6983267 suggests selection of the risk allele in somatic colorectal tumor evolution.
|
18172290 |
2008 |
|
rs6983267
|
|
|
0.730 |
GeneticVariation |
BEFREE |
Three polymorphisms (rs10808555, rs6983267 and rs7837328) located between 128.47 and 128.54 Mb were found to be associated with colorectal tumor risk.
|
18535017 |
2008 |
|
rs6983267
|
|
|
0.730 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism (SNP), rs6983267, in the chromosome 8q24 region, has been associated with higher risk for colorectal neoplasms, but its relation to carcinogenic mechanisms is unclear.
|
24115145 |
2014 |
|
rs121913343
|
|
|
0.710 |
GeneticVariation |
BEFREE |
We further demonstrate by glutathione-S-transferase (GST) pull-down and coimmunoprecipitation that PBF binds to the tumor suppressor protein p53, as well as to p53 mutants (Δ126-132, M133K, V197E, G245D, I255F and R273C) identified in the colorectal tumors.
|
25408419 |
2016 |
|
rs16969681
|
|
|
0.710 |
GeneticVariation |
BEFREE |
The intestine-specific transcription factor CDX2 and Wnt effector TCF7L2 bound near rs16969681, with significantly higher affinity for the risk allele, and CDX2 overexpression in CDX2/GREM1-negative cells caused re-expression of GREM1. rs16969681 influences CRC risk through effects on Wnt-driven GREM1 expression in colorectal tumors.
|
25131200 |
2014 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
To verify the technical characteristics of the microarray system for the correct identification of the KRAS mutational status at the two hotspot codons 12 and 13 and of the BRAF(V600E) mutation in colorectal tumor, we selected 75 samples previously characterized by conventional and CO-amplification at Lower Denaturation temperature-PCR (COLD-PCR) followed by High Resolution Melting analysis and direct sequencing.
|
23536897 |
2013 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our results support the use of VE1 IHC for identification of colorectal neoplasms harboring the BRAF V600E mutation.
|
25517872 |
2015 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Recently, a V599E hotspot mutation within the BRAF gene was reported in a high percentage of colorectal tumors and significantly associated to defective mismatch repair (MMR).
|
14668801 |
2003 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The major aim of this study was to evaluate the performance of anti-BRAF V600E (VE1) antibody in colorectal tumors with and without KRAS mutation.
|
29127628 |
2019 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Evaluation of high-resolution melting analysis as a diagnostic tool to detect the BRAF V600E mutation in colorectal tumors.
|
19213871 |
2009 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In addition, a significant association between mismatch-repair (MMR) deficiency and the V599E mutation in colorectal tumors has been found.
|
14654916 |
2004 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Secondly, considering the alternative possibility, we identified genes whose DNA hypermethylation was closely linked to BRAF(V600E) and CIMP in 235 primary colorectal tumors.
|
20027224 |
2009 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Rac1b overexpression and B-Raf(V600E) are significantly associated in primary colorectal tumors (P = .008) and colorectal cell lines.
|
18602919 |
2008 |
|
rs121913377
|
|
|
0.090 |
GeneticVariation |
BEFREE |
BRAF V600E mutation testing of colorectal tumors demonstrating aberrant MLH1 protein expression by IHC was the most common secondary tumor test, with 53% of laboratories performing the test; 15% of laboratories also applied the BRAF V600E test to endometrial tumors with aberrant MLH1 expression despite no evidence for its utility.
|
30294856 |
2018 |
|
rs1463038513
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The I1307K mutation is common among Jews who have had colorectal neoplasms, but overall it was found to have little effect clinically in the current study group.
|
15959913 |
2005 |
|
rs1463038513
|
|
|
0.030 |
GeneticVariation |
BEFREE |
The APC variants I1307K and E1317Q are associated with colorectal tumors, but not always with a family history.
|
9724771 |
1998 |