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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.
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19251870 |
2009 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Patients with late-onset depression had an increased rate of the C677T MTHFR gene mutation and other vascular risk factors.
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11722155 |
2001 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We found a significant contribution of the MTHFR 677C>T polymorphic variants to depression in postmenopausal women.
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18801628 |
2008 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
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22668858 |
2012 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
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12796225 |
2003 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).
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23285094 |
2012 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.
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21772318 |
2012 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.
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21125200 |
2010 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).
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26681493 |
2016 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
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23116396 |
2013 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk.
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28968218 |
2017 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
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23900311 |
2013 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.
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17074966 |
2007 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
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26177556 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
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22739363 |
2012 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism in recurrent major depressive disorder; influence of antidepressant use and depressive state?
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25012419 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
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24532086 |
2014 |
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rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T is associated with MA in individuals selected for depression study.
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21635773 |
2011 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
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22520017 |
2012 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
Stratification for anxious versus nonanxious depression revealed a significantly detrimental effect of the less active 5-HTTLPR S allele (p = 0.007) and 5-HTTLPR/5-HTT rs25531 haplotypes on treatment response in patients with anxious depression.
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20588071 |
2010 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
Gender-specific association between serotonin transporter polymorphisms (5-HTTLPR and rs25531) and neuroticism, anxiety and depression in well-defined healthy Han Chinese.
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27788383 |
2017 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
Seeking to explain the adolescent gender difference in depression, this study examined the effects of 5-HTTLPR (rs25531), the monoamine oxidase A-upstream variable number tandem repeat (MAOA-uVNTR), and negative life events (NLE).
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22836288 |
2013 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
To further delineate the impact of 5-HTT gene variation on psychopathology in depression, in this analysis the influence of the 5-HTTLPR and the functionally closely related 5-HTT rs25531 was investigated in 340 Caucasian patients with a major depressive episode (DSM-IV) with particular attention to the subtype of depression (melancholic depression versus atypical depression) applying logistic regression models adjusted for age and gender.
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18050262 |
2008 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
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20515362 |
2010 |
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rs25531
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0.100 |
GeneticVariation |
BEFREE |
The aim of our work is to study the possible role of clinical variables, neuropsychological performance, and the 5HTTLPR, rs25531, and val108/58Met COMT polymorphisms on the prediction of depression remission after 12 weeks' treatment with fluoxetine.
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24446536 |
2012 |