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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The BDNF Val66Met polymorphism, resting-state hippocampal functional connectivity and cognitive deficits in acute late-onset depression.
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26000753 |
2015 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The results suggest that in males, BDNF Val66Met interacts with childhood life events, increasing the cognitive susceptibility markers of depression.
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22033217 |
2012 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The aim of this study was to assess the genetic contribution of BDNF Val66Met functional polymorphism to AD-related depression.
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18179845 |
2009 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Allelic differences in the brain-derived neurotrophic factor Val66Met polymorphism in late-life depression.
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17911362 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Our objectives were to: 1) compare plasma BDNF levels in medicated patients with depression and controls; 2) assess the effect of ECT on plasma BDNF levels in medicated patients with depression; 3) explore the relationship between plasma BDNF levels and the Val66Met (rs6265) BDNF polymorphism; and 4) examine the relationship between plasma BDNF levels and clinical symptoms and outcomes with ECT.
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29802070 |
2019 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03).
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24433458 |
2014 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005).
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17632285 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research.
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17700574 |
2007 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
We therefore examined whether the single-nucleotide polymorphism producing a valine-to-methionine substitution at codon 66 (val66met) of the BDNF gene was associated with childhood NE, in the context of parental depression and relationship discord.
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20921572 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A meta-analysis of studies was conducted to compare the frequency of the BDNF Val66Met variant between cases with geriatric depression and age-matched controls.
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22610920 |
2012 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Association between BDNF Val66Met polymorphism and trait depression is mediated via resting EEG alpha band activity.
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18721847 |
2008 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Imaging genetics studies have investigated the influence of the serotonin transporter-linked polymorphic region (5HTTLPR) and brain-derived neurotrophic factor (BDNF) Val66Met polymorphism on the hippocampus in healthy individuals and patients with depression (MDD).
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21692988 |
2011 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The serotonin transporter polymorphism (5-HTTLPR) and the brain-derived neurotrophic factor (BDNF) val66met polymorphism have both been linked to depression symptoms and to depression diagnosis (MDD) in interaction with adversity; there have also been failures to find the effects.
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21420735 |
2011 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The present findings indicate the gender differences in the effect of Val66Met genotype on the cortisol responses to stress protocol, and extend the evidence for the importance of gender and the role of Val66Met in the modulation of stress reactivity and subsequent depression prevalence.
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28249185 |
2017 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
These results indicate that there was a lack of association between severity of depression and BDNF Val66Met polymorphism in Chinese patients with MDD.
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20016225 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The current study examined the effects of val66met, 5-HTTLPR, and family environment quality on youth depressive symptoms in adolescence and young adulthood in a longitudinal sample oversampled for maternal depression history.
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25347540 |
2014 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
5-HTTLPR and BDNF VAL66MET, functional polymorphisms of the serotonin (5-HT) transporter (SLC6A4) and brain-derived neurotrophic factor (BDNF) gene, impact on two distinct, but interacting signaling systems, which have been related to depression and to the modulation of neurogenesis and plasticity of circuitries of emotion processing.
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18347599 |
2008 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
In the total sample, the BDNF Val66Met polymorphism was not significantly associated with depression.
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18852698 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Val66Met functional polymorphism and serum protein level of brain-derived neurotrophic factor (BDNF) in acute episode of schizophrenia and depression.
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29331787 |
2018 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The results suggest that interactions may occur after stresses among BDNF Val66Met, gender and time course to influence dep</span>ression.
|
28527683 |
2017 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
There was no interaction between depression and Val66Met genotype status.
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25188405 |
2014 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
Interactions between BDNF Val66Met polymorphism and early life stress predict brain and arousal pathways to syndromal depression and anxiety.
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19153574 |
2009 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
The authors hypothesize that other factors may have a stronger effect on hippocampal structure in older individuals and that the association between the Val66Met polymorphism and geriatric depression is mediated through other mechanisms.
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20220593 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A single nucleotide polymorphism in the human BDNF gene (Val66Met) affects memory, and influences Alzheimer's disease and depression vulnerability in a sex-specific manner.
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20097294 |
2010 |
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rs759834365
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0.100 |
GeneticVariation |
BEFREE |
A multivariable linear regression model showed that the best predictors of depression were the SF-36 General health (β = -0.209; P = 0.013), Mental health (β = -0.410; P < 0.001) and Social activity (β = -0.195; P = 0.035) scores; physical disability (assessed by the Extended Disability Status Scale score) was directly correlated to depression severity on univariate analysis, but it was not a relevant predictor of depression on multivariate analysis; other variables directly related to the disease (treatment, annual relapsing rate) and the BDNF Val66Met polymorphism were not significantly associated with depression.
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26756166 |
2016 |