rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
No statistically significant difference was observed when global DNA methylation were stratified according to C677T MTHFR genotypes (p = 0.7200), BMI (p = 0.1170), smoking habit (p = 0.4382), physical activity in daily life (p = 0.8492), scored cognitive function (p = 0.7229) or depression state (p = 0.8301).
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23285094 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Significance of dietary folate intake, homocysteine levels and MTHFR 677 C>T genotyping in South African patients diagnosed with depression: test development for clinical application.
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24532086 |
2014 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
To investigate the modifying effects of two candidate genes (serotonin transporter gene linked promoter region (5-HTTLPR) and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms) on the associations between general somatic morbidity and incidence of depression in an East Asian population with high frequencies of potential risk alleles.
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19251870 |
2009 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Overall, T variant of MTHFR C677T gene polymorphism was significantly associated with an increased risk of depression in the Chinese population (T vs. C: OR = 1.52, 95% CI = 1.24-1.85; TT + CT vs. CC: OR = 1.64, 95% CI = 1.16-2.30; TT vs. CC: OR = 2.19, 95% CI = 1.49-3.24; TT vs. CC + CT: OR = 1.80, 95% CI = 1.31-2.46).
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26681493 |
2016 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Patients with late-onset depression had an increased rate of the C677T MTHFR gene mutation and other vascular risk factors.
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11722155 |
2001 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
This meta-analysis demonstrates an association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder, raising the possibility of the use of folate in treatment and prevention.
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17074966 |
2007 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Interaction between the MTHFR C677T polymorphism and traumatic childhood events predicts depression.
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23900311 |
2013 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Low folate is unlikely to be an important risk factor for depression during pregnancy and for postpartum depression, but may be a risk factor for depression outside of pregnancy, especially among women with the MTHFR C677T TT genotype.
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21772318 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In conclusion results of present meta-analysis supports that there is a significant association between MTHFR C677T polymorphism and depression risk, and MTHFR 677T allele contributes to increased risk of depression in Asian individuals.
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26177556 |
2014 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Folate, vitamin B12, homocysteine, and the MTHFR 677C->T polymorphism in anxiety and depression: the Hordaland Homocysteine Study.
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12796225 |
2003 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
We found a significant contribution of the MTHFR 677C>T polymorphic variants to depression in postmenopausal women.
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18801628 |
2008 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Present meta-analysis supports that there is a meager significant association between MTHFR C677T polymorphism and depression risk.
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28968218 |
2017 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
The current study did not find evidence of an association between the MTHFR C677T TT genotype and impaired cognition or depression in a population with adequate folate status and a high prevalence of cognitive impairment and depression.
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22739363 |
2012 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
MTHFR C677T is associated with MA in individuals selected for depression study.
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21635773 |
2011 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
In addition, the C677T-MTHFR association adds further support to existing findings underscoring the potential role of folate in depression.
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21125200 |
2010 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
A common C677T polymorphism in MTHFR has been associated with an increased risk for the development of cardiovascular disease, Alzheimer's disease, and depression in adults, and of neural tube defects in the fetus.
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23116396 |
2013 |
rs1217691063
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0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that MTHFR C677T polymorphism may be linked more to loneliness than depression in the cognitively normal elderly males, and may be implicated in the pathophysiology of late-life depression in relation to MTHFR genes.
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22668858 |
2012 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
Stratification for anxious versus nonanxious depression revealed a significantly detrimental effect of the less active 5-HTTLPR S allele (p = 0.007) and 5-HTTLPR/5-HTT rs25531 haplotypes on treatment response in patients with anxious depression.
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20588071 |
2010 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
Although preliminary, these findings identify anhedonia as a promising mechanism linking 5-HTTLPR/rs25531 genotype and stress to depression.
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22094432 |
2012 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
We hypothesize that functional polymorphisms (TPH2: rs7305115, 5-HTTLPR and rs25531) within both genes contribute to the risk of depressive disorders after childhood abuse in adult life.
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25214390 |
2014 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (MTHFR) C-(677)T, brain-derived neurotrophic factor (BDNF) val66met and tryptophan hydroxylase-2 (TPH2) G-(703)T. Regression analyses were performed using the six SNPs as independent variables: Model 1 with response (percentage Hamilton Depression (HAMD) change from baseline to endpoint) as the dependent variable and Model 2 with adverse event index as the dependent variable (Bonferroni corrected p-value < 0.025).
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20515362 |
2010 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
Unmedicated, young adults with low current depression and anxiety symptoms (N=106) were genotyped for the 5-HTTLPR, including the single nucleotide polymorphism (SNP) rs25531 in the long allele of the 5-HTTLPR.
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20694965 |
2010 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
The 5-HTTLPR polymorphism in the gene's promoter region has a short (S) and a long (L) allele, of which L contains a further SNP (rs25531), resulting in a triallelic polymorphism: La, Lg, and S. Both S and Lg result in increased serotonin signaling (to simplify, we refer to both alleles as 'S'), which in turn appears associated with depression vulnerability, specifically in individuals with stressful events.
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26232751 |
2015 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
Using a large twin sample of 3,243 individuals from 2,230 families aged 18-95 years (mean = 32.3, SD = 13.6) we investigate the interaction between 5HTTLPR (subtyped with SNP rs25531) and stressful events on risk of depression and suicidality using both ordinal regressions and item response theory analyses.
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19911410 |
2010 |
rs25531
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0.100 |
GeneticVariation |
BEFREE |
1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
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22520017 |
2012 |