|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Diabetes genomics research has illuminated single nucleotide polymorphism (SNP) in several genes including, fat mass and obesity associated (FTO) (rs9939609 and rs9926289), potassium voltage-gated channel subfamily J member 11 (rs5219), SLC30A 8 (rs13266634) and peroxisome proliferator-activated receptor gamma 2 (rs1805192).
|
31823921 |
2019 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Pro12Ala missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus.
|
9918859 |
1999 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
16393309 |
2006 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A common polymorphism at codon 12 of this gene (Pro12Ala) has been shown to confer protection against diabetes and colorectal cancer.
|
17763950 |
2008 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Across all studies, the Pro12Ala polymorphism had no significant effect on diabetes-related traits.
|
17065690 |
2006 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Adiponectin values did not differ among these two genotypes even when categorized based on their diabetes status (normal glucose tolerance Pro12Pro 7.9 vs. Pro12Ala 7.7 microg/ml, P = 0.994; diabetes Pro12Pro 4.7 vs. Pro12Ala 5.4 microg/ml, P = 0.622).
|
17335469 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Another PPARγ polymorphism, the C1431T, is in strong linkage disequilibrium with Pro12Ala and has been shown to be associated with body weight, but its association with diabetes is controversial.
|
21795447 |
2011 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Both diabetes populations were typed for the PPARg Pro12Ala polymorphism, to replicate this well-supported association (Altshuler et al.2000).
|
12096349 |
2002 |
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rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Cumulative rather than synergistic effects of PPARG Pro12Ala and APM1 SNPs on diabetes risk are suggested.
|
16567542 |
2006 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Effect of the PPARG2 Pro12Ala polymorphism and clinical risk factors for diabetes mellitus on HbA1c in the Japanese general population.
|
23006958 |
2012 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphism of peroxisome proliferator-activated receptor-gamma 2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects.
|
17941898 |
2008 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotyping for Pro12Ala and Trp64Arg polymorphism in postmenopausal women may have the clinical benefit of predicting hyperglycaemia, thereby contributing to the prevention of diabetes mellitus development in the future.
|
29464546 |
2018 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings shows the association of these two polymorphisms with serum triglyceride levels, which was increased in the order of P12P-CC < P12P-CT < P12A-CC < P12A-CT in the CHD patients with diabetes.
|
21833536 |
2011 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings suggest that Pro12Ala PPAR-gamma gene polymorphism may be protective against IR and might prevent the development of diabetes mellitus in the first-degree relatives of subjects with PCOS.
|
16316841 |
2005 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
PPARG P12A (rs1801282) was not significantly associated with diabetes or related traits.
|
17903298 |
2007 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Proliferator-activated receptor gamma Pro12Ala interacts with the insulin receptor substrate 1 Gly972Arg and increase the risk of insulin resistance and diabetes in the mixed ancestry population from South Africa.
|
24447396 |
2014 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Studies on the association of the Pro12Ala and C1431T polymorphisms of PPAR? with diabetes and obesity have revealed extensive population-dependent variations.
|
19805902 |
2009 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism is not directly associated with obesity, hypertension or diabetes in this population.
|
11248748 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes.
|
11289058 |
2001 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism was more associated with plasma lipids and fasting glucose concentrations, whereas the C1431T polymorphism was related to the risk of diabetes.
|
14729856 |
2004 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of PPAR-gamma 2 is associated with decreased risk of diabetes mellitus.
|
16881538 |
2006 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has been associated with decreased risk of diabetes and obesity, both disorders linked to cognitive impairment.
|
17052804 |
2008 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The P12A variant of isoform gamma is estimated to reduce diabetes risk by 19% in many populations, and has a large attributable risk because of high prevalence of the normal allele.
|
18388689 |
2008 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The Pro12Ala variant in the peroxisome proliferator-activated receptor gamma (PPARG) gene has been associated with diabetes and several cancers.
|
19436234 |
2009 |
|
rs1805192
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The authors highlight these challenges and biases using an illustrative example: meta-analysis of interactions between the Pro12Ala variant of the peroxisome proliferator-activated receptor gamma (PPARgamma) gene and various diet and lifestyle factors in the risk of diabetes.
|
20406760 |
2010 |