Variant | Gene | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||
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0.090 | GeneticVariation | BEFREE | The influence of exposure to diabetes in utero and the HNF-1α G319S polymorphism on the metabolic phenotype of youth with T2DM at diagnosis is unknown. | 27087001 | 2016 |
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0.090 | GeneticVariation | BEFREE | When participants were stratified by baseline smoking status, HNF1A G319S carriers who were active smokers had increased risk of developing diabetes (OR 6.91 [95% CI 3.38-14.12]), while the association was attenuated to non-significance among non-smokers (1.11 [0.40-3.08]). | 21208426 | 2011 |
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0.090 | GeneticVariation | BEFREE | All of the 7 offspring with diabetes have 1 or 2 copies of the G319S polymorphism. | 21429061 | 2011 |
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0.090 | GeneticVariation | BEFREE | We aimed to investigate whether CRP was mediating the association between HNF1A G319S and type 2 diabetes in an Aboriginal Canadian population with a high prevalence of diabetes. | 20716378 | 2010 |
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0.090 | GeneticVariation | BEFREE | A combination of abnormal splicing and reduced activity of the G319S protein may explain the diabetes susceptibility. | 18586913 | 2008 |
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0.090 | GeneticVariation | BEFREE | Sigmoidal modeling showed that each dose of the G319S allele accelerated the median age of diabetes onset by about 7 yr. | 12726923 | 2003 |
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0.090 | GeneticVariation | BEFREE | The demonstration of a functional consequence for HNF1A G319S provides a mechanistic basis for its strong association with Oji-Cree type 2 diabetes and its unparalleled specificity for diabetes prediction in these people, in whom diabetes presents a significant public health dilemma. | 11904371 | 2002 |
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0.090 | GeneticVariation | BEFREE | This makes the HNF1A G319S genotype the most specific predictive genetic test for diabetes in any human population. | 11286643 | 2001 |
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0.090 | GeneticVariation | BEFREE | Despite the failure of linkage analysis to identify HNF1A as a determinant of type 2 diabetes, we feel justified in interpreting that G319S has a very important pathogenic role in Oji-Cree diabetes, based upon the highly suggestive association studies. | 10807546 | 2000 |