Three of the 12 SNPs in COL11A1, rs1676486 (<i>P</i>=0.026, OR = 2.089, 95% CI = 1.092-3.996), rs3753841 (<i>P</i>=0.036, OR = 1.886, 95% CI = 1.038-3.426), and rs12138977 (<i>P</i>=0.024, OR = 2.133, 95% CI = 1.104-4.123) were found to have a significant association with PACG.
Our study suggests that rs1676486 and rs12138977 in COL11A1 as well as rs216489 and rs11024102 in PLEKHA7 are associated with an increased risk of PAC/PACG in the Han Chinese population, supporting prior reports of the association of COL11A1 and PLEKH7 with angle closure glaucoma.