|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Decreased glioma risk was observed with the XRCC1 rs1799782 variant (P(trend) .04).
|
20150366 |
2010 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conclude that XRCC1 Arg399Gln polymorphism is a significant risk factor, and 399Gln (G) allele carries a 3.5 times greater risk for glioma, while PARP1 Val/Ala genotype may be protective against it.
|
20868244 |
2010 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The XRCC1 Arg399Gln polymorphism may be a useful susceptibility biomarker for glioma.
|
22320953 |
2011 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
These results suggest that the XRCC1 Arg399Gln might influence the risk of developing glioma in a Han population in northeastern Chinese.
|
22951806 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In the stratified analysis by ethnicity, the XRCC1 Arg399Gln</span> polymorphism had a higher risk of glioma development among Asians (for Gln vs Arg: OR = 1.34, 95 % CI 1.12-1.61; for GlnGln vs ArgArg: OR = 1.72, 95 % CI 1.18-2.51; for ArgGln vs ArgArg: OR = 1.31, 95 % CI 1.01-1.71; for GlnGln/ArgGln vs ArgArg: OR = 1.41, 95 % CI 1.10-1.80; for GlnGln vs ArgArg/ArgGln: OR = 1.48, 95 % CI 1.05-2.09)., but not among Caucasians.
|
23096083 |
2013 |
|
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A total of 11 studies (3,810 cases and 6,079 controls), 7 studies (2,928 cases and 5,048 controls), and 4 studies (1,461 cases and 2,593 controls) were finally included in the analyses of the association between XRCC1 Arg399Gln, Arg194Trp, and Arg280His polymorphisms and glioma risk, respectively.
|
23167420 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our comprehensive analysis of nine SNPs in eight genes suggests that the rs730437 and rs1468727 in ERGF, rs1799782 in XRCC1 gene, and rs861539 in XRCC3 gene are associated with glioma risk.
|
23244079 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Our meta-analysis suggested that Arg399Gln polymorphism was associated with increased risk of glioma among Asians and borderline increased risk for glioblastoma among Caucasians, whereas Arg194Trp/Arg280His polymorphisms might have no influence on the susceptibility of glioma in different ethnicities.
|
23383237 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma.
|
23712607 |
2013 |
|
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg399Gln, Arg194Trp, and Arg280His have drawn attention because of their potential associations with the development of glioma.
|
23712607 |
2013 |
|
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The rs2276466 G/G genotype was significantly associated with a moderate increased risk of glioma (OR=1.82, 95% CI=1.10-3.02) in a codominant model, and variation of rs25489 was associated with a 1.31- and 1.78-fold glioma risk in dominant and recessive models, respectively.
|
23911298 |
2013 |
|
rs148611340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.1779C>G, the genotype GG was statistically associated with the increased risk of glioma compared to wild genotype CC (OR = 1.80, 95% CI 1.17-2.78, P = 0.007).
|
23918303 |
2014 |
|
rs25490
|
|
|
0.010 |
GeneticVariation |
BEFREE |
As for c.910A>G, the risk of glioma</span> for genotype GG was significantly higher than wild genotype AA (odds ratio (OR) = 1.98, 95% confidence interval (CI) 1.33-2.94, P = 0.001).
|
23918303 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that XRCC1 Arg194Trp and Arg399Gln polymorphisms were associated with the risk of glioma.
|
24048757 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study suggested that XRCC1 Arg194Trp and Arg399Gln polymorphisms were associated with the risk of glioma.
|
24048757 |
2014 |
|
rs25489
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Three polymorphisms of X-ray repair cross-complementing groups 1 (XRCC1) Arg194Trp, Arg280His, and Arg399Gln may be associated with the individual susceptibility to glioma.
|
24048757 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, our work also points out the importance of new studies for Arg399Gln association in some cancer types, such as glioma, gastric cancer, and oral cancer, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg399Gln polymorphism in cancer development.
|
24205095 |
2013 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the meta-analysis suggest a potential decreased susceptibility to glioma in association with the XRCC1 Arg39</span>9Gln polymorphism, especially in Asians.
|
24258108 |
2014 |
|
rs72554204
|
|
|
0.010 |
GeneticVariation |
BEFREE |
These preliminary findings indicate that the c.1471G>A genetic polymorphism of XRCC1 has the potential to influence glioma susceptibility, and might be used as molecular marker for assessing glioma risk.
|
24289608 |
2013 |
|
rs1214285376
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
|
rs199613843
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
|
rs2307191
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We detected that the alleles/genotypes were statistically associated with the increased risks of glioma (for c.482C>T, TT versus (vs.) CC: OR = 2.24, 95% CI = 1.48-3.39, P < 0.001; T vs. C: OR = 1.30, 95% CI = 1.09-1.53, P = 0.003; for c.1161G>A, AA vs. GG: OR = 1.62, 95% CI = 1.11-2.35, P = 0.012; A vs. G: OR = 1.19, 95% CI = 1.01-1.41, P = 0.040; for c.1804C>A, AA vs. CC: OR = 2.12, 95% CI = 1.45-3.11, P < 0.001; A vs. C: OR = 1.32, 95% CI = 1.12-1.56, P = 0.001).
|
24375631 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
No evidence of significant associations between ERCC2 rs1799793, OGG1 rs1052133, XRCC1 rs25489, XRCC1 rs1799782, or XRCC3 rs861539 and risk of glioma was observed.
|
24500421 |
2014 |