|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This study shows that there was no association between the polymorphism rs11200638 in HTRA1 gene and response to anti-VEGF treatment of exudative AMD.
|
28637435 |
2017 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We confirmed the association of age-related maculopathy susceptibility 2 (ARMS2) rs10490924 (P=7.38 × 10<sup>-17</sup>), HTRA1 rs11200638 (P=5.47 × 10<sup>-17</sup>) and complement factor H gene (CFH) rs800292 (P=2.53 × 10<sup>-8</sup>) with neovascular AMD, all loci passing the genome-wide significance level (P<5.22 × 10<sup>-8</sup>).
|
28703135 |
2017 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Rs12153855C and rs9391734A alleles could further increase the susceptibility to AMD in subjects with rs800292, rs11200638 and rs429608 risk alleles.
|
26861912 |
2016 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, the rs11200638-rs2672598 joint genotype AA-CC conferred higher risk to exudative AMD (43.11 folds) than PCV (3.68 folds).
|
27338780 |
2016 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Eight single nucleotide polymorphisms (SNPs) from 6 genes of the HDL metabolism pathway and 2 known AMD-associated SNPs, rs800292 (from complement factor H [CFH]) and rs11200638 (from HtrA serine peptidase 1 [HTRA1]), were genotyped in all study subjects using the TaqMan genotyping technology (Applied Biosystems, Foster City, CA).
|
24393350 |
2014 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
FPR1 rs78488639 interacted with CFH rs800292, HTRA1 rs11200638, and smoking, enhancing risk to exudative AMD and PCV.
|
25277308 |
2014 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The association of SKIV2L rs429608 with neovascular AMD remained significant after adjusting for CFH rs800292 and HTRA1 rs11200638.
|
23260260 |
2013 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genotypes of 3 polymorphisms in known AMD susceptibility loci (rs1061170 in complement factor H (CFH), rs11200638 in HTRA1 and rs1413711 in VEGF) were determined.
|
24080590 |
2013 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Significant associations with both exudative AMD and PCV were observed in 11 of them and HTRA1 rs11200638</span>, with different genotypic distributions between exudative AMD and PCV (P < 0.001).
|
22491416 |
2012 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped two SNPs that are located in the LOC387715 locus (rs10490924) and HTRA1 (rs11200638) in 137 cases of exudative AMD and 187 controls.
|
20456446 |
2010 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We observed that homozygous risk genotypes (TT in rs10490924 and AA in rs11200638) were more strongly associated with AMD than the heterozygous genotypes (GT in rs10490924 and geographic atrophy in rs11200638) for both SNPs.
|
19491722 |
2009 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The ORs of exudative AMD for individuals carrying one copy risk allele and two copy risk alleles were 2.57 (1.21 - 5.45) and 4.76 (2.15 - 10.55) respectively, with correspondent PARs of 28.3% (2.0% - 40.5%) and 38.2% (21.8% - 45.4%). rs11200638 in HTRA1 was another susceptible locus for AMD and the risk homozygotes were significantly susceptible for exudutive AMD (OR = 3.98, 1.88 - 8.43) with PAR of 38.9% (24.3% - 45.8%).
|
19187590 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Many single-nucleotide polymorphisms (SNPs), including the previously reported variants rs10490924 (hypothetical LOC387715/ARMS2) and rs11200638 (HTRA1), defined 2 significant haplotypes associated with increased risk of neovascular AMD.
|
18164066 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
There was no significant difference in the incidence of CFH Y402H (P = 0.598) and HTRA1 rs11200638 (P = 0.290) between eyes with typical exudative AMD and with PCV.
|
18939352 |
2008 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The HTRA1 promoter polymorphism, rs11200638, is a strong candidate with a functional consequence that predisposes Japanese to develop neovascular AMD.
|
17438519 |
2007 |
|
rs11200638
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Homozygotes for the risk allele at rs11200638 had a 6.33-fold increased risk of PCV and a 13.77-fold increased risk of wet AMD when compared with homozygotes for the wild-type allele.
|
17692272 |
2007 |