|
rs10189761
|
|
|
0.010 |
GeneticVariation |
BEFREE |
SNPs rs10189761 and rs737337 were identified, for the first time, as independent predictors of major clinical outcomes in patients with HF.
|
31209632 |
2019 |
|
rs1022113606
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Risk of cardiovascular disease and heart failure was higher in R213G heterozygotes versus non-carriers in diabetic subjects, but not in non-diabetic subjects.
|
26844281 |
2015 |
|
rs1022113606
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Substitution of arginine by glycine at amino acid 213 (R213G) of its HBD was first identified in patients with heart failure, followed by many studies that focused on the role of this variant (SOD3(R213G)) in ischemic heart disease and cardiovascular disease.
|
25927599 |
2015 |
|
rs1028728
|
|
|
0.010 |
GeneticVariation |
BEFREE |
rs3829365 was associated with heart failure (P = 0.043), whereas rs1028728 was not (P = 0.188).
|
21558869 |
2011 |
|
rs10401969
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Pleiotropic Meta-Analyses of Longitudinal Studies Discover Novel Genetic Variants Associated with Age-Related Diseases.
|
27790247 |
2016 |
|
rs10423928
|
|
|
0.010 |
GeneticVariation |
BEFREE |
From these, rs10189761 and rs737337 variants were independently associated with HF prognosis (HR 2.295 (1.287-4.089, 95% CI); p = 0.005), whereas rs10423928, rs1800437, rs737337 and rs9351814 were related with bad prognosis only in obese patients (HR 2.142 (1.438-3.192, 95% CI); p = 0.00018).
|
31209632 |
2019 |
|
rs1042713
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
rs1042713
|
|
|
0.040 |
GeneticVariation |
BEFREE |
ADRB2 polymorphism Arg16Gly modifies the natural outcome of heart failure and dictates therapeutic response to β-blockers in patients with heart failure.
|
30374408 |
2018 |
|
rs1042713
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Arginine 16 glycine beta2-adrenoceptor polymorphism and cardiovascular structure and function in patients with heart failure.
|
17336757 |
2007 |
|
rs1042713
|
|
|
0.040 |
GeneticVariation |
BEFREE |
Beta-2 adrenergic receptor gene polymorphisms Gln27Glu, Arg16Gly in patients with heart failure.
|
19886995 |
2009 |
|
rs1042714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Single nucleotide polymorphisms (SNPs) within the β(1)- (Ser49Gly, Arg389Gly) and β(2)-adrenoceptor (Arg16Gly, Gln27Glu, Thr164Ile) have been associated with alterations in adrenoceptor (AR) function sensitivity in vitro and in vivo and possibly contribute to HF progression.
|
20803192 |
2010 |
|
rs1042714
|
|
|
0.020 |
GeneticVariation |
BEFREE |
There was no difference in the prevalence of polymorphism Gln27Glu between HF patients and control subjects.
|
28933308 |
2018 |
|
rs10455872
|
|
|
0.010 |
GeneticVariation |
BEFREE |
This study sough to test whether elevated lipoprotein(a) levels and corresponding LPA risk genotypes (low number of kringle IV type 2 repeats, rs3798220 and rs10455872, minor allele carriers) are associated with an increased risk of heart failure (HF).
|
26656145 |
2016 |
|
rs10501920
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Also, rs10501920 in CNTN5 was associated with AF (p = 9.4 x 10(-6)) and HF (p = 1.2 x 10(-4)).
|
17903304 |
2007 |
|
rs10519210
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
|
20445134 |
2010 |
|
rs10519210
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
|
20445134 |
2010 |
|
rs1061622
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The methionine 196 arginine polymorphism of the TNF receptor 2 gene (TNFRSF1B) is not associated with worse outcomes in heart failure.
|
22921902 |
2012 |
|
rs10757274
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The GG genotype of rs10757274 on chromosome 9p21, which has been shown to increase CHD risk, is also associated with increased HF risk among whites.
|
19329499 |
2009 |
|
rs10927887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Individual genotyping of rs10927887 in the two study populations and a third independent heart failure cohort (combined n = 5,489) revealed an additive allele effect on heart failure risk that is independent of age, sex, and prior hypertension (odds ratio = 1.27 per allele copy; P = 8.3 × 10(-7)).
|
21248228 |
2011 |
|
rs10927887
|
|
|
0.020 |
GeneticVariation |
BEFREE |
A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.
|
23850580 |
2013 |
|
rs10932374
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The G-G-C-C-T haplotype of rs10932374</span>-rs13003941-rs1595064-rs1595065-rs3748960 in the ErbB4 gene increased the risk of heart failure (odd ratio 1.35, 95% confidence interval [CI] 1.06-1.70; P = .014).
|
26844763 |
2016 |
|
rs11006544
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs111033560
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Strikingly, both individuals homozygous for L39stop developed dilated cardiomyopathy and heart failure, requiring cardiac transplantation at ages 16 and 27.
|
12639993 |
2003 |
|
rs11110004
|
|
|
0.700 |
GeneticVariation |
GWASCAT |
Genetics of heart rate in heart failure patients (GenHRate).
|
31113495 |
2019 |
|
rs11172782
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
|
20445134 |
2010 |