|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
High frequencies of a favorable IL-28B rs8099917 polymorphism and the clinical implications in patients with HCV in one multiracial area of Taiwan.
|
28962822 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Host DNA from all HCV positive patients and age- and sex-matched non-HCV-infected control individuals were analysed for IL28B single nucleotide polymorphism (SNP) (rs12979860 and rs8099917).
|
30865664 |
2019 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, higher glucose levels were found in T2D patients carrying the IL28B CT/TT rs12979860 and GT/GG rs8099917 HCV risk genotypes compared to those with the protective CC and TT genotype (p=0.06 and p=0.02, respectively).
|
27664841 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did find that the four IL28B variants were in complete linkage disequilibrium (r(2) = 0.831-0.922), and the frequency of rs8099917 G</span>T genotype was significantly higher among chronic HCV-infected patients than among controls (OR = 2.21, 95% CI = 1.33-3.68, P = 0.00193); the G allele was found more frequently in the chronic HCV-infected group than in the control group (OR = 2.10, 95% CI = 1.28-3.44, P = 0.00276).
|
24144988 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B (rs8099917 and rs12979860) and IL10 (rs1800896) polymorphisms alone, or in combination, are good predictors of therapeutic response in HCV-3a patients.
|
29340806 |
2018 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B (rs12979860 and rs8099917) single nucleotide polymorphisms (SNPs) have been recently found among the Pakistani population associated with response to chronic HCV infection INF-α + ribavirin therapy.
|
26177560 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B gene polymorphism rs12979860, but not rs8099917, contributes to the occurrence of chronic HCV infection in Uruguayan patients.
|
29499724 |
2018 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B rs12979860 and rs8099917 polymorphisms were predictors of therapy response in HCV genotypes 1, 2 and 3 subjects from an admixed population.
|
22098416 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B rs12979860 and rs8099917 single nucleotide polymorphisms are significantly associated with SC of HCV infection.
|
23611115 |
2013 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B rs12979860 CC and rs8099917 TT are strong SVR predictors for PEG IFN-α/ribavirin-treated HCV-1 patients, regardless of ethnicity.
|
22591106 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IL28B SNP rs8099917 "G" was associated with absence of treatment-induced clearance (odds ratio [OR] 2.19, p = 1.27×10(-8), 1.67-2.88) and absence of spontaneous clearance (OR 3.83, p = 1.71×10(-14), 2.67-5.48) of HCV, as was rs12979860, with slightly lower ORs.
|
21931540 |
2011 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Impact of donor and recipient single nucleotide polymorphisms of IL28B rs8099917 in living donor liver transplantation for hepatitis C.
|
24599320 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Importantly, MTs were significantly upregulated (in contrast to most other ISGs) in HCV-infected liver biopsies of rs8099917 responders.
|
24335707 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In hepatitis C virus genotype 1, the OR (95% CI) for rapid and sustained virological response for the wild-type ss469415590 TT was 9.88 (1.99-48.99) and 7.25 (1.91-27.51), respectively, similar to those found for rs12979860 CC [9.55 (1.93-47.37) and 6.30 (1.71-23.13)] and for rs12980275 AA [9.62 (1.94-47.77] and 7.83 (2.02-30.34)], but higher than for rs8099917 TT [4.8 (1.73-13.33) and 4.75 (2.05-10.98)].
|
24308755 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition to rs4803217, also single nucleotide polymorphisms (SNPs) (rs12979860, rs8099917 and rs12980275) of known significance in predicting of HCV clearance were analyzed.
|
28638221 |
2017 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In addition, the association of IL28B rs8099917 genotype with baseline data, including HCV RNA level, HCV genotype, histological activity grade, fibrosis stage, and body mass index, were evaluated and further stratified by covariant factors.
|
27751759 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In adjusted analyses, low plasma maxi-LVP level was independently associated with spontaneous HCV clearance (≤827 IU/ml; adjusted odds ratio 3.98, 95% CI: 1.02, 15.51, P = 0.047), after adjusting for interferon lambda-3 rs8099917 genotype, estimated duration of HCV infection and total HCV RNA level.
|
27224844 |
2016 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we showed that IL-28 polymorphism rs8099917 strongly predicts virological response in HCV infection and that real-time PCR with Zip nucleic acid probes is a sensitive, specific and rapid detection method for detection of SNPs which will be essential for monitoring patients undergoing antiviral therapy.
|
25773845 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In participants with HCV genotype 1, unfavorable genotypes for HCV clearance near IFNL3 were associated with increased HCC risk, the adjusted odds ratio (95% CI) for rs12979860 and rs8099917 being 1.73 (1.00-2.99) and 1.84 (1.02-3.33), respectively.
|
26602024 |
2015 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, serum apoB-100 concentration might be an informative marker for judging changes in HCV-associated intracellular lipoprotein metabolism in patients carrying the rs8099917 responder genotype.
|
21879313 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In patients achieving rapid virological response, favourable CC/TT allele at rs12979860, rs8099917 was found to be predominant at both the alleles at 77%, 73.2% respectively; whereas in case of patients with relapsed HCV infection CT, TG alleles were found to be predominant.
|
24914551 |
2014 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In this study, the genotype frequency of two IL28B SNPs (rs129679860 and rs8099917) in a cohort of chronic HCV-monoinfected patients in Brazil was evaluated and the SNP sufficient to predict the treatment response outcome was determined.
|
23147144 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interleukin-28B (IL28B) single nucleotide polymorphism (SNP) influences viral response (VR) to interferon (IFN) therapy in patients with hepatitis C. We studied the relationship between VR and the IL28B polymorphism (rs8099917) in patients on long-term pegylated IFN plus ribavirin (PEGIFN/RBV) therapy for recurrent hepatitis C after living-donor liver transplantation (LDLT).
|
22432893 |
2012 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interleukin-28B rs12979860C/T and rs8099917T/G contribute to spontaneous clearance of hepatitis C virus in Caucasians.
|
23266640 |
2013 |
|
rs8099917
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Moreover, we found that IL28B rs8099917 G variants (TG+GG) interact with HCV genotype 1(G1) to result in higher risk of NVR (P=0.009), and that they are also associated with HBV DNA reactivation (TG+GG vs. TT, P=0.005).
|
24147097 |
2013 |