|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Strong linkage disequilibrium of IFNL4 rs12979860 with IFNL4 rs368234815, which is casually associated with HCV spontaneous and therapeutical eradication, at least partially explains favorable HCV outcomes attributed to major homozygosity in rs12979860.
|
30027841 |
2019 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the genetic ability to generate IFN-λ4, determined by the presence of the rs368234815-ΔG allele, is the strongest predictor of impaired clearance of hepatitis C virus (HCV) infection in humans.
|
31241411 |
2019 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An interferon λ4 gene (IFNL4) knockout allele (rs368234815; TT) is associated with spontaneous and IFN-α-dependent cure of hepatitis C virus infection.
|
30289470 |
2019 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The recently described rs368234815 TT/ΔG dinucleotide and rs117648444 nonsynonymous P70S polymorphisms in IFN lambda 4 (IFNL4) gene, which are strongly associated with response to IFN in hepatitis C virus (HCV) infection, could be also useful in IFN-treated CHB patients.
|
28732143 |
2018 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We used RNA sequencing (RNA-Seq) to examine whether IFNL4 genetic variation (rs368234815) modulates ISG expression in peripheral blood mononuclear cells (PBMC) during chronic HCV infection.
|
29165633 |
2018 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In chronic hepatitis C virus (HCV) infections, where the IFNL variants were first identified to be associated with response to interferon-α-ribavirin therapy, the available data clearly suggests that the causal variant could be the dinucleotide polymorphism rs368234815 that causes an open reading frame-shift in the IFNL4 gene resulting in expression of a functional IFN-λ4, a new type III IFN.
|
29705128 |
2018 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We genotyped the rs368234815 polymorphism in 87 patients with chronic HCV by PCR sequencing and PCR-RFLP methods, simultaneously.
|
28057801 |
2017 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
To analyze the genetic heterogeneity of the Amerindian and admixed population (Mestizos) based on the IL28B (rs12979860, rs8099917) and IFNL4 (rs368234815) haplotypes, and their association with spontaneous clearance (SC) and liver damage in patients with hepatitis C infection from West Mexico.
|
26741362 |
2016 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The aim of the present study was to verify the genotype frequencies of SNPs rs8099917, rs12979860 and rs368234815 and to evaluate the association between SNPs and the outcome of HCV infection, taking into account the population ancestry.
|
26973228 |
2016 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We conducted genetic analysis of rs368234815 in a chronic HCV patient cohort and molecular studies of IFNL4 in primary human hepatocytes (PHHs).
|
25577150 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The TT variant of rs8099917 near IFNL3 was associated with increased spontaneous HCV RNA clearance, with an adjusted odds ratio (95% CI) of 2.78 (1.43-5.39), as was the newly-identified TT/TT dinucleotide variant rs368234815 near IFNL4 (adjusted odds ratio 2.68, 95% CI: 1.42-5.05).
|
26602024 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Analysis of 126 participants with recent HCV infection from the Australian Trial in Acute Hepatitis C study demonstrated the prevalence of favorable single-nucleotide polymorphisms were 62%, 51%, and 45% for rs8099917 TT, rs12979860 CC, and rs368234815 TT/TT, respectively.
|
26150150 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IFNL4-ΔG/TT (rs368234815) genotype is associated with hepatitis C virus clearance and may play a role in other infections.
|
26431156 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The interferon (IFN)L4 polymorphism rs368234815 is associated with hepatitis C virus (HCV) spontaneous clearance and response to IFN-based treatments.
|
26372394 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Genetic polymorphisms within the interferon lambda (IFN-λ) region are strongly associated with hepatitis C virus (HCV) clearance; the IFNL4-ΔG/TT (rs368234815) polymorphism, which controls the generation of IFN-λ4 protein, is more strongly associated with HCV clearance than rs12979860 (the 'IL28B variant').
|
26186989 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The rs368234815-ΔG allele is strongly associated with decreased clearance of hepatitis C virus (HCV) infection.
|
26134097 |
2015 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Interferon-λ4-related dinucleotide variant rs368234815 TT/-G is strongly linked with rs12979860 polymorphism, the most important genetic marker connected to treatment-induced hepatitis C virus clearance.
|
24724563 |
2014 |
|
rs368234815
|
|
|
0.100 |
GeneticVariation |
BEFREE |
IFN-λ4 can be generated only by individuals who carry the IFNL4-ΔG allele (rs368234815), which is the strongest known host factor for predicting clearance of HCV.
|
24786669 |
2014 |