|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Hypertension association reached genome-wide significance for the two variants, specifically, P=7.3 × 10(-10) for AGT rs699 and P=3.9 × 10(-8) for CYP11B2 rs1799998.
|
22456346 |
2012 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of AGT has been studied extensively in many populations including Japanese, and the results suggest a weak, but significant linkage with hypertension.
|
11128865 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T and T174M variants do not contribute to the increased risk of CHD or hypertension in the Indian population.
|
12938141 |
2003 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and insertion/deletion polymorphism of the angiotensin-1 converting enzyme gene in essential arterial hypertension in Caucasians.
|
17448297 |
2007 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
M235T polymorphism of the angiotensinogen gene and hypertension in Chinese.
|
9794717 |
1998 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A case-control association study was conducted to investigate a possible involvement of polymorphisms of three renin-angiotensin system genes: ACE (I/D and T-3892C), AGT (M235T and T174M), and AT1R (A1166C) in the early development of hypertension.
|
16876684 |
2006 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension.
|
7635961 |
1995 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
A multiple logistic regression analysis showed that age (odds ratio [OR]: 1.07, 95% confidence interval [95% CI]: 1.06-1.08), body mass index (BMI) (OR: 1.18, 95% CI: 1.13-1.23), alcohol consumption (OR: 1.39, 95% CI: 1.16-1.66), family history of hypertension (OR: 1.57, 95% CI: 1.18-2.07), and combined AGT M235T Thr/Thr and ADD1 Trp/Trp polymorphisms (OR: 1.37, 95% CI: 1.03-1.82) were associated with hypertension.
|
16392768 |
2005 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
After adjusting for age, sex, body mass index, hypertension, left atrial volume index (LAVI) and other covariates, M235T increased the risk of AF recurrence in additive and dominant models with odds ratios of 2.023 (95% confidence interval (CI): 1.034-3.926, p=0.033) and 2.601 (95% CI: 1.102-6.056, p=0.025), respectively.
|
26240116 |
2015 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Although AGT M235T was not associated with the development of hypertension in either sex, men with M235T TT were found to be at an increased risk of IgAN progression compared to those with the other genotypes (p = 0.019).
|
19729965 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
An association was found between rs5186, rs699, and hypertension under allele contrast and homozygous codominant models (odds ratio, 1.63 [95% confidence interval, 1.04-2.54] and 4.01 [95% confidence interval, 1.17-13.80] for rs5186, respectively; and 1.80 [95% confidence interval, 1.13-2.87] for rs699).
|
29520984 |
2018 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen M235T genotype was associated with a stepwise increase in angiotensinogen levels in white subjects and a corresponding increase in risk of hypertension in both white and Asian subjects.
|
12805070 |
2003 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants, sodium intake and hypertension among non-drinking, lean Japanese men and women.
|
10994750 |
2000 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Angiotensinogen T174M and M235T variants and hypertension in the Hani and Yi minority groups of China.
|
19365726 |
2009 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Binary odds ratios showed significant association between the M268T polymorphism and hypertension in both populations.
|
21312059 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Conflicting results are to be found in the literature on the relationship between the M235T polymorphism of the angiotensinogen (AGT) gene and hypertension.
|
16755155 |
2006 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Earlier studies suggested that a single nucleotide polymorphism (SNP) that converts methionine to threonine at amino acid 235 is associated with hypertension in the Caucasian population.
|
15854165 |
2006 |
|
rs4762
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Evidence on the effect of salt intake on the interaction between angiotensinogen (AGT) T174M polymorphism and high blood pressure is sparse.
|
15055256 |
2004 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
First, a contingency chi-square analysis was carried out to test for an association between the M235T polymorphism and hypertension status.
|
7649545 |
1995 |
|
rs5049
|
|
|
0.020 |
GeneticVariation |
BEFREE |
Four polymorphisms, located in the ACE (rs4291), angiotensinogen (rs5049) and (pro)renin receptor (rs2968915; rs5981008) genes were significantly associated with hypertension in two vascular disease populations of CAD (EUROPA) and cerebrovascular disease (PROGRESS; n = 3571).
|
21157371 |
2011 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
18413162 |
2008 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Furthermore, an M235T variant of the angiotensinogen (AGT) gene has been associated with hypertension, an important risk factor for the development and progression of diabetic nephropathy.
|
9049480 |
1997 |
|
rs699
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Gene polymorphisms of adducin GLY460TRP, ACE I/D, AND AGT M235T in pediatric hypertension patients.
|
25262176 |
2014 |