|
rs1057518965
|
|
T |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1336343565
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555119899
|
|
C |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs1555257073
|
|
C |
0.700 |
CausalMutation |
CLINVAR |
|
|
|
|
rs1555908409
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs3218716
|
|
T |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs74315329
|
|
A |
0.700 |
GeneticVariation |
CLINVAR |
|
|
|
|
rs128620185
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One amino acid substitution (R28H) was found in the pleckstrin homology domain's residue, which is mutated in mice bearing the X-linked immunodeficiency phenotype; another substitution (R307G) was identified in the src homology domain 2.
|
9143921 |
1997 |
|
rs128621195
|
|
|
0.010 |
GeneticVariation |
BEFREE |
One amino acid substitution (R28H) was found in the pleckstrin homology domain's residue, which is mutated in mice bearing the X-linked immunodeficiency phenotype; another substitution (R307G) was identified in the src homology domain 2.
|
9143921 |
1997 |
|
rs201137953
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
|
11067872 |
2000 |
|
rs61732239
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency.
|
11067872 |
2000 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs1131691021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs1444669684
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We show here that the expression of K-ras(G12V) oncogene in a near diploid HPV16-E6E7 gene immortalized human pancreatic duct epithelial cell line originally derived from normal pancreas induced the formation of carcinoma in 50% of severe combined immunodeficient mice implanted with these cells.
|
15958547 |
2005 |
|
rs1131691021
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In contrast, the combination of p53 RNAi knockdown with expression of oncogenic H-Ras(G12V) transformed the p16-deficient BAR-T cells, as evidenced by their loss of contact inhibition, by their formation of colonies in soft agar, and by their generation of tumors in immunodeficient mice.
|
20927195 |
2010 |
|
rs762846821
|
|
|
0.020 |
GeneticVariation |
BEFREE |
In contrast, the combination of p53 RNAi knockdown with expression of oncogenic H-Ras(G12V) transformed the p16-deficient BAR-T cells, as evidenced by their loss of contact inhibition, by their formation of colonies in soft agar, and by their generation of tumors in immunodeficient mice.
|
20927195 |
2010 |
|
rs121913237
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Enhanced engraftment of AE/N-Ras(G12D) cells was observed on intrafemoral injection into immunodeficient mice, presumably because of improved survival in the bone marrow microenvironment.
|
21200020 |
2011 |
|
rs1482518887
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Enhanced engraftment of AE/N-Ras(G12D) cells was observed on intrafemoral injection into immunodeficient mice, presumably because of improved survival in the bone marrow microenvironment.
|
21200020 |
2011 |
|
rs746540053
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Enhanced engraftment of AE/N-Ras(G12D) cells was observed on intrafemoral injection into immunodeficient mice, presumably because of improved survival in the bone marrow microenvironment.
|
21200020 |
2011 |
|
rs778036161
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Enhanced engraftment of AE/N-Ras(G12D) cells was observed on intrafemoral injection into immunodeficient mice, presumably because of improved survival in the bone marrow microenvironment.
|
21200020 |
2011 |
|
rs121912438
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Previously, we established that facial MN (FMN) survival levels in the SOD1(G93A) transgenic mouse model of ALS are reduced and nerve regeneration is delayed, similar to immunodeficient RAG2(-/-) mice, after facial nerve axotomy.
|
24911596 |
2014 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Here we present the first formal evidence of the shared and independent ability of basal cells and luminal progenitors, isolated from normal human mammary tissue and transduced with a single oncogene (KRAS(G12D)), to produce serially transplantable, polyclonal, invasive ductal carcinomas within 8 weeks of being introduced either subrenally or subcutaneously into immunodeficient mice.
|
26633636 |
2015 |
|
rs121434592
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Expression of exogenous copies of AKT1(E17K) in MCF10A breast epithelial cells increased phosphorylation of AKT and its substrates, induced colony formation in soft agar, and formation of lesions in the mammary fat pad of immunodeficient mice.
|
26351323 |
2015 |
|
rs121913529
|
|
|
0.030 |
GeneticVariation |
BEFREE |
Intrabone marrow transplantation into immunodeficient mice further showed that MA4 and KRAS(G12V) alone or in combination enhanced hematopoietic repopulation without impairing myeloid-lymphoid differentiation, and that mutated KRAS did not cooperate with MA4 to initiate leukemia.
|
26837759 |
2016 |