rs11209026
|
|
A |
0.900 |
GeneticVariation |
GWASDB |
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
|
17068223 |
2006 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The IL-23R allele was negatively associated with inflammatory bowel disease (IBD): the R381Q SNP was undertransmitted in children with IBD (8 transmitted [T] versus 27 untransmitted [UT]; P = 0.001).
|
17309073 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Analysis accounting for Arg381Gln suggested that other loci within IL23R also influence IBD susceptibility.
|
17484863 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Arg381Gln (rs11209026) non-synonymous SNP was most significantly associated with IBD protection (odds ratio, 0.4; 95% confidence interval, 0.3-0.7).
|
17678845 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
IL23R is an IBD susceptibility gene, but has no epistatic interaction with CARD15 and SLC22A4/5. rs1004819 is the major IL23R variant associated with CD in the German population, while the p.Arg381Gln IL23R variant is a protective marker for CD and UC.
|
17786191 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To analyse the frequency of p.Arg381Gln in three independent European inflammatory bowel disease cohorts and to evaluate how this variant influences disease behaviour.
|
17877509 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Distribution of the relevant alleles was compared between controls and IBD patients. rs11209026 and rs2241880 genotype distributions were examined both within IBD clinical subphenotypes and CARD15 genotypes.
|
17894849 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
IL23R R381Q and ATG16L1 T300A are strongly associated with Crohn's disease in a study of New Zealand Caucasians with inflammatory bowel disease.
|
17894849 |
2007 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs11209026 SNP in IL23R had a protective effect for IBD in the case-control analysis (odds ratio [OR] 0.19, 95% confidence interval [CI] 0.10-0.37, P= 6.6E-09).
|
18047540 |
2008 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The primary SNP of interest in a previous study of inflammatory bowel disease (IBD) (Arg381Gln; rs11209026) was found to be protective against AS in the Newfoundland population (P=0.04) and in the Toronto population (P=0.04) in single-marker univariate analysis.
|
18383363 |
2008 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASDB |
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
|
18758464 |
2008 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
GWASCAT |
Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease.
|
18758464 |
2008 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
These results suggest that the IL-23R Arg381Gln seems not to be involved in the genetic predisposition to IBD in a Chilean population, and confirms that there are ethnic differences in the genetic background of IBD.
|
19103525 |
2008 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The Arg381Gln variant, which has a strong protective effect against inflammatory bowel disease, showed no association with AA.
|
19165485 |
2009 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
To replicate the association of IL23R R381Q (rs11209026) with inflammatory bowel disease (IBD), examine the effect of the two nonsynonymous variations, Q3H and L310P, on IBD, and to study gender distribution of these variants in IBD patients.
|
19294505 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
This may result from the fact that rs11209026, the nonsynonymous SNP in IL23R, is not polymorphic in Chinese patients, providing further evidence that rs11209026 is the key polymorphism associated with AS (and likely inflammatory bowel disease and psoriasis) in this gene.
|
19877036 |
2009 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
The rs11209026 and rs7517847 nucleotide substitutions were determined in 353 German children with IBD (221 CD, 132 UC) and 253 controls using pre-designed TaqMan((R)) SNP genotyping assays.
|
20192940 |
2010 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our study suggests that variants in the NOD2 gene and the protective variant R381Q in IL23R are not associated with IBD in Indians.
|
21155887 |
2011 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASCAT |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs11209026
|
|
G |
0.900 |
GeneticVariation |
GWASDB |
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
|
23128233 |
2012 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
After Bonferroni correction for multiple testing, both the homozygous and the heterozygous variant genotypes of IL23R G>A(rs11209026) (OR(CD,adj): 0.38, 95% CI: 0.21-0.67, p = 0.03; OR(IBD,adj) 0.43, 95% CI: 0.28-0.67, p = 0.007) and PTPN22 1858 G>A(rs2476601) (OR(CD,unadj) 0.54, 95% CI: 0.41-0.72, p = 7*10-4; OR(IBD,unadj): 0.61, 95% CI: 0.48-0.77, p = 0.001) were associated with reduced risk of CD.
|
24971461 |
2014 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Variants of IL23R gene were investigated for association with many diseases like chronic inflammatory disorders, RA, inflammatory bowel diseases and the susceptibility to the development of gastric cancer but no data are available concerning the association of IL23R gene (rs11209026) polymorphism with HCC development in HCV patients.
|
25666505 |
2015 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Interestingly, a functional single nucleotide polymorphism (SNP) in the IL-23 receptor gene (IL-23R; rs11209026, 1142 G wild-type A reduced function, Arg381Gln, R381Q) seems to confer a measure of protection against development of inflammatory bowel disease (IBD; Crohn's disease, ulcerative colitis), ankylosing spondylitis, rheumatoid arthritis, psoriasis, thyroiditis, recurrent spontaneous abortion and asthma, suggesting that a perturbation in the IL-23 signaling pathway is likely to be relevant to the pathophysiology of these diseases.
|
27043356 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
In conclusion, our study demonstrated that the p.Val362Ile and Arg381Gln were not associated with susceptibility to IBD in Chinese Han population.
|
27765927 |
2016 |
rs11209026
|
|
|
0.900 |
GeneticVariation |
BEFREE |
Our meta-analysis demonstrated that the rs11209026 polymorphism might be a protective factor against developing IBD, while the rs10889677 polymorphism might be a risk factor for IBD.
|
31728561 |
2020 |