DisGeNET - a database of gene-disease associations

Chronic Lymphocytic Leukemia, C0023434

Variant: rs1045642 ×

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs1045642

ABCB1

0.040

GeneticVariation

BEFREE

Our results demonstrate the high frequency of C allele of ABCB1 T3435C in B-CLL patients with Kurdish ethnicity.

25586345

2015

dbSNP:

rs1045642

ABCB1

0.040

GeneticVariation

BEFREE

Here, we investigated whether common MDR1 single nucleotide polymorphisms (SNPs) (C1236T, C3435T, and G2677T/A) affect predisposition to chronic lymphocytic leukemia (CLL).

21463115

2011

dbSNP:

rs1045642

ABCB1

0.040

GeneticVariation

BEFREE

MDR-1 polymorphisms (G2677T and C3435T) in B-chronic lymphocytic leukemia: an impact on susceptibility and prognosis.

20496015

2011

dbSNP:

rs1045642

ABCB1

0.040

GeneticVariation

BEFREE

Taken together, these data indicate that the MDR1 C3435T SNP may carry an increased risk of developing B-CLL, possibly by virtue of decreased protection against P-gp-substrate carcinogens.

17085864

2007