|
rs121913502
|
|
|
0.780 |
GeneticVariation |
BEFREE |
IDH2 mutations included R140Q (n=3; one post-PMF AML, one post-PV AML and one PMF) and a novel R140W (n=1; mutation found in both chronic- and blast-phase samples).
|
20410924 |
2010 |
|
rs267606870
|
|
|
0.710 |
GeneticVariation |
BEFREE |
IDH2 mutations included R140Q (n=3; one post-PMF AML, one post-PV AML and one PMF) and a novel R140W (n=1; mutation found in both chronic- and blast-phase samples).
|
20410924 |
2010 |
|
rs121913502
|
|
T |
0.780 |
CausalMutation |
CLINVAR |
Intriguingly, the IDH2 mutation p.R140Q and novel IDH1 mutation p.I99M co-occurred in a 75-year-old patient with AML developed from myelodysplastic syndromes (MDS).
|
20946881 |
2010 |
|
rs121913502
|
|
|
0.780 |
GeneticVariation |
BEFREE |
Intriguingly, the IDH2 mutation p.R140Q and novel IDH1 mutation p.I99M co-occurred in a 75-year-old patient with AML developed from myelodysplastic syndromes (MDS).
|
20946881 |
2010 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
rs121913503
|
|
|
0.720 |
GeneticVariation |
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
rs1042026735
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
rs200758694
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
rs773159667
|
|
|
0.010 |
GeneticVariation |
BEFREE |
We found three missense (p.R132C, p.R132G, and p.I99M; occurred in five patients) and one silent mutation (c.315C>T; occurred in two patients) in the IDH1 gene and two missense mutations (p.R140Q and p.R172K; occurred in four AML patients) and one silent mutation (c.435G>A) in the IDH2 gene.
|
20946881 |
2010 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
Evaluation of mutations in the isocitrate dehydrogenase genes in therapy-related and secondary acute myeloid leukaemia identifies a patient with clonal evolution to IDH2 R172K homozygosity due to uniparental disomy.
|
21250968 |
2011 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation.
|
21596855 |
2011 |
|
rs121913502
|
|
A |
0.780 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs121913502
|
|
T |
0.780 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs121913503
|
|
A |
0.720 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs267606870
|
|
A |
0.710 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs1057519736
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
rs121913502
|
|
T |
0.780 |
CausalMutation |
CLINVAR |
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients.
|
22397365 |
2012 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
Molecular alterations of isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) metabolic genes and additional genetic mutations in newly diagnosed acute myeloid leukemia patients.
|
22397365 |
2012 |
|
rs121913502
|
|
A |
0.780 |
CausalMutation |
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
rs121913503
|
|
A |
0.720 |
CausalMutation |
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
rs121913503
|
|
T |
0.720 |
CausalMutation |
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
rs267606870
|
|
A |
0.710 |
CausalMutation |
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
rs1057519736
|
|
G |
0.700 |
CausalMutation |
CLINVAR |
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia.
|
22417203 |
2012 |
|
rs121913502
|
|
|
0.780 |
GeneticVariation |
BEFREE |
IDH mutations occurred at a considerable frequency of 15.89% in Chinese AML cases; IDH2 R140Q was the most frequent genetic alteration and was associated with older age, normal karyotype, and French-American-British classification M2 at diagnosis.
|
22494415 |
2012 |