|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Conclusion The rs2004640 T allele and TT genotype and GTA haplotype of rs rs10954213, rs2004640, and rs2280714, respectively, can be considered as risk factors for the development of SLE.
|
28059021 |
2017 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A significant association was observed between the IRF5 markers (rs2004640, rs10954213) and susceptibility to SLE (p < 0.0001) and OP (p < 0.025).
|
24697591 |
2015 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
And a three-way interaction between TYK2 rs280500, rs2304256 and IRF5 rs10954213 and SLE was found (p < 0.0001).
|
26294277 |
2015 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
In a subgroup analysis by ethnicity, significantly increased SLE risk was associated with IRF5 rs2004640 T allele in populations of European, Asian and Latin American origin, and the rs10954213 A allele is significantly associated with SLE in European origin but not in Asian origin.
|
21834935 |
2011 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We corroborated the association of the promoter indel with SLE in 5 different populations and revealed that rs10954213 is the main single-nucleotide polymorphism responsible for altered IRF5 expression in PBMC.
|
20080916 |
2010 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
We found evidence for genetic interaction (p = 0.014) between rs2304256 in TYK2 and rs10954213 in IRF5, both members of the type I IFN pathway, strengthening the role of the type I IFN pathway in the pathogenesis of SLE.
|
19567624 |
2009 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
A case-control association study was performed for rs2004640 as well as for rs10954213 and rs2280714, all of which were previously reported to be associated with SLE, in 281 SSc patients and 477 healthy controls.
|
19479858 |
2009 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
The CGGGG indel explains the association signal from multiple SNPs in the IRF5 gene, including rs2004640, rs10954213 and rs729302 previously considered to be causal variants in SLE.
|
18063667 |
2008 |
|
rs10954213
|
|
|
0.090 |
GeneticVariation |
BEFREE |
Haplotypes carrying the T alleles of rs2004640 and rs2280714 and the A allele of rs10954213 are over-transmitted in SLE families.
|
17189288 |
2007 |