|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
SLE protection was associated with TYK2 risk infection variants affecting residually its catalytic domain, rs12720356 (OR = 0.308; p = 0.041) and rs34536443 (OR = 0.370; p = 0.034), but not with rs2304256, rs12720270, and rs280500.
|
31434951 |
2019 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We concluded that IFIH1 rs1990760_T and TYK2 rs2304256_C alleles were significantly associated with SLE, and IL-10 rs1800896 GG homozygote might have an enhancement effect on SLE risk.
|
30171347 |
2018 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
rs2304256
|
|
C |
0.770 |
GeneticVariation |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
And a three-way interaction between TYK2 rs280500, rs2304256 and IRF5 rs10954213 and SLE was found (p < 0.0001).
|
26294277 |
2015 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
This meta-analysis shows that the rs6445975 polymorphism of PXK and the rs2304256 polymorphism of TYK2 are associated with the development of SLE in Europeans.
|
22592861 |
2012 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
The highest association was at marker rs2304256 (odds ratio (OR) = 0.86; 95%CI = 0.82-0.90) in the TYK2 gene, which has previously been associated with systemic lupus erythematosus and multiple sclerosis.
|
19966805 |
2010 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
In order to test for its genetic association with SLE in a Japanese population, TYK2 single nucleotide polymorphisms (SNPs), rs2304256, rs12720270 and rs280519, were genotyped.
|
19440814 |
2009 |
|
rs2304256
|
|
|
0.770 |
GeneticVariation |
BEFREE |
We found evidence for genetic interaction (p = 0.014) between rs2304256 in TYK2 and rs10954213 in IRF5, both members of the type I IFN pathway, strengthening the role of the type I IFN pathway in the pathogenesis of SLE.
|
19567624 |
2009 |