|
rs377566281
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In addition to tumour stage, which is an important prognostic factor affecting to the survival of stomach cancer patients, the genetic variant Gln339Arg in XRCC1 may non-significantly contribute to risk of stomach cancer death among Thai people.
|
26320504 |
2015 |
|
rs148611340
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analyses suggested that these two genetic variants were statistically associated with the increased risk of gastric cancer (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17-1.77; for c.1779C>G, G versus C: OR = 1.51, 95% CI 1.22-1.86).
|
24779987 |
2014 |
|
rs2293035
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The association analyses suggested that these two genetic variants were statistically associated with the increased risk of gastric cancer (for c.1254C>T, T versus C: odds ratio (OR) = 1.44, 95% confidence interval (CI) 1.17-1.77; for c.1779C>G, G versus C: OR = 1.51, 95% CI 1.22-1.86).
|
24779987 |
2014 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer.
|
27706710 |
2016 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models.
|
21604176 |
2012 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
The authors performed a systematic review and meta-analysis of associations of the x-ray repair cross-complementing 1 gene (XRCC1) single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, and Arg399Gln with gastric cancer risk, based on eligible studies retrieved from electronic databases for the period January 2000-December 2009.
|
21216841 |
2011 |
|
rs25489
|
|
|
0.060 |
GeneticVariation |
BEFREE |
In our association study between three amino acid substitution polymorphisms of XRCC1 (Arg194Trp, Arg280His, and Arg399Gln) and the risk of gastric cancer in the Korean population, none of the polymorphisms were associated with increased risk of gastric cancer.
|
12359351 |
2002 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, we did not find any association of polymorphism of XRCC1 Arg399Gln (OR = 1.56; 95% CI: 0.32-7.82) and XPD Lys751Gln (OR = 0.46; CI: 0.10-2.19) with GC risk in the study population.
|
30225185 |
2018 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, we suggest that the XRCC1 gene Arg194Trp polymorphism is associated with gastric cancer susceptibility in the Chinese population.
|
27706710 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that XRCC1 gene rs25487 polymorphism might play a leading role in pronounced susceptibility to gastric cancer in Han Chinese.
|
26590607 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
We additionally found that the variant 399Gln allele in Arg399Gln SNP was associated with a greater risk of developing gastric cancer.
|
27221877 |
2016 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, the XRCC1 Arg399Gln and Arg280His polymorphisms were shown to have no influence on the development of gastric cancer.
|
27706710 |
2016 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
However, significant associations between Arg194Trp polymorphism and gastric cancer were found in Asian.
|
25335737 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our meta-analysis indicates that genetic polymorphism of the XRCC1 Arg399Gln and Arg280His do not have an association with gastric cancer risk.
|
25335737 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to obtain a comprehensive and reliable assessment of the relationships between XRCC1 Arg399Gln and XPD Lys751Gln polymorphisms and the clinical outcomes of gastric cancer (GC) patients treated with oxaliplatin-based chemotherapy.
|
24590266 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
This meta-analysis aimed to summarize published data about the association between two SNPs of XRCC1 (Arg194Trp and Arg399Gln) and treatment outcomes of patients with advanced gastric cancer.
|
24465544 |
2014 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The data suggest that the XRCC1 Arg399Gln polymorphism may be a prognostic biomarker of OS for platinum-based gastric cancer treatment.
|
24634242 |
2014 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
Our findings demonstrated that the genetic variant Arg280His in XRCC1 may contribute to cancer progression and that XRCC1 Arg194Trp variants may act as a favorable prognostic indicator of resected GC, particularly among the diffuse-type GC.
|
23425027 |
2013 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In conclusion, XRCC1 Arg194Trp homozygous mutant genotype (Trp/Trp) was found to be associated with increased risk of GC.
|
21604176 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
In particular, individuals with the XRCC1 Arg194Trp variant genotype are at increased risk for GC below 60 years old.
|
23317230 |
2012 |
|
rs1799782
|
|
|
0.100 |
GeneticVariation |
BEFREE |
ADPRT Val762Ala and XRCC1 Arg194Trp polymorphisms and risk of gastric cancer in Sichuan of China.
|
22901183 |
2012 |
|
rs25487
|
|
|
0.100 |
GeneticVariation |
BEFREE |
The results of the overall meta-analysis did not suggest any association between Arg280His/Arg399Gln polymorphisms and GC susceptibility for all genetic models.
|
21604176 |
2012 |